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Jiajie Guo

Bio: Jiajie Guo is an academic researcher from University of Macau. The author has contributed to research in topics: Apoptosis & DNA damage. The author has an hindex of 14, co-authored 15 publications receiving 1144 citations.

Papers
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TL;DR: Recent advances in in vitro and invivo research on the anti-cancer effects and related mechanisms of some promising natural products isolated from Chinese medicinal herbs are summarized.
Abstract: In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), alkaloids (berberine), terpenes (artemisinin, β-elemene, oridonin, triptolide, and ursolic acid), quinones (shikonin and emodin) and saponins (ginsenoside Rg3), which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed.

338 citations

Journal ArticleDOI
Xiuping Chen1, Jiajie Guo1, Jiaolin Bao1, Jin-Jian Lu1, Yitao Wang1 
TL;DR: A systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones is provided, aiming to bring new insights for further research and development of this ancient herb.
Abstract: Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing blood stasis) herb with 1000 years of clinical application. It mainly contains two groups of ingredients: the hydrophilic phenolic acids and the lipophilic tanshinones. Both groups have demonstrated multiple bioactivities, such as antioxidative stress, antiplatelet aggregation, anti-inflammation, among others. Recent data have demonstrated that its lipophilic compounds, especially the tanshinones, show potent anticancer activities both in vitro and in vivo. The anticancer effects of the hydrophilic phenolic acids have also been reported. Furthermore, tanshinones provide structural skeletons for chemical modifications, allowing for a series of derivatives of interests. This review provides a systematic summary of the anticancer profile and the underlying mechanisms of the bioactive compounds isolated from Danshen with special emphasis on tanshinones, aiming to bring new insights for further research and development of this ancient herb.

214 citations

Journal ArticleDOI
TL;DR: The present study summarizes the achievements of the 50 years of research on cucurbitacins and systematically analyze their bioactivities with an emphasis on their anticancer effects.
Abstract: Cucurbitacin and its derivatives (cucurbitacins) are a class of highly oxidized tetracyclic triterpenoids. They are widely distributed in the plant kingdom, where they act as heterologous chemical pheromones that protect plants from external biological insults. Their bioactivities first attracted attention in the 1960s. Documented data demonstrate that cucurbitacins possess strong pharmacological properties, such as antitumor, anti-inflammatory, and hepatoprotective effects, etc. Several molecular targets for cucurbitacins have been discovered, such as fibrous-actin, signal transducer and activator of transcription 3, cyclooxygenase-2, etc. The present study summarizes the achievements of the 50 years of research on cucurbitacins. The aim was to systematically analyze their bioactivities with an emphasis on their anticancer effects. Research and development has shed new insight into the beneficial properties of these compounds.

129 citations

Journal ArticleDOI
TL;DR: The results have advanced the current understandings of the anti-cancer mechanisms of GADM and induced DNA fragmentation and cleavage of PARP which are the characteristics of apoptosis and decreased the mitochondrial membrane potential in MCF-7 cells.

111 citations

Journal ArticleDOI
TL;DR: This review aims to summarize and analyze the current knowledge on the anti-cancer properties and mechanisms of G. lucidum triterpenoids (GLTs) and discuss the future prospects of the application of GLTs in cancer treatment.
Abstract: Introduction: Triterpenoids isolated from Ganoderma lucidum are a class of naturally occurring compounds and structurally highly oxidized lanostanes. Accumulated data show that triterpenoids exhibi...

102 citations


Cited by
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TL;DR: This review focuses on the current understanding of the tumor promoting and the tumor suppressive functions of ROS, and highlights the potential mechanism(s) involved, and sheds light on a very novel and an actively growing field of ROS‐dependent cell death mechanism referred to as ferroptosis.

666 citations

Journal ArticleDOI
TL;DR: This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB

387 citations

Journal ArticleDOI
28 Nov 2014-Science
TL;DR: Along the way, Shang et al. have worked out the biosynthetic pathway of cucurbitacin and discovered genetic traces of the domestication process and unraveled the mystery of why some cucumbers, if grown in chilly conditions, become bitter.
Abstract: Cucurbitacins are triterpenoids that confer a bitter taste in cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. These compounds discourage most pests on the plant and have also been shown to have antitumor properties. With genomics and biochemistry, we identified nine cucumber genes in the pathway for biosynthesis of cucurbitacin C and elucidated four catalytic steps. We discovered transcription factors Bl (Bitter leaf) and Bt (Bitter fruit) that regulate this pathway in leaves and fruits, respectively. Traces in genomic signatures indicated that selection imposed on Bt during domestication led to derivation of nonbitter cucurbits from their bitter ancestors.

337 citations

Journal ArticleDOI
TL;DR: A growing body of reports supports the evidence that berberine has anticancer effects, being able to block the proliferation of and to kill cancer cells.

333 citations

Journal ArticleDOI
Jin-Jian Lu1, Jiaolin Bao1, Xiuping Chen1, Min Huang1, Yitao Wang1 
TL;DR: Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloid properties can be made.
Abstract: Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made.

320 citations