J
Jian He
Researcher at Academy of Military Medical Sciences
Publications - 21
Citations - 765
Jian He is an academic researcher from Academy of Military Medical Sciences. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 9, co-authored 18 publications receiving 333 citations.
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Journal ArticleDOI
Deciphering human macrophage development at single-cell resolution
Zhilei Bian,Yandong Gong,Tao Huang,Christopher Z. W. Lee,Christopher Z. W. Lee,Lihong Bian,Zhijie Bai,Hui Shi,Yang Zeng,Chen Liu,Jian He,Jie Zhou,Xianlong Li,Zongcheng Li,Yanli Ni,Chunyu Ma,Lei Cui,Rui Zhang,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Lai Guan Ng,Yu Lan,Florent Ginhoux,Bing Liu,Bing Liu,Bing Liu +25 more
TL;DR: The data represent a comprehensive characterization of the spatiotemporal dynamics of early macrophage development during human embryogenesis, providing a reference for future studies of the development and function of human TRMs.
Journal ArticleDOI
Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing
Yang Zeng,Jian He,Zhijie Bai,Zongcheng Li,Yandong Gong,Chen Liu,Yanli Ni,Junjie Du,Chunyu Ma,Lihong Bian,Yu Lan,Bing Liu +11 more
TL;DR: This work constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis, and revealed the cellular components of the putative aortic niche and potential cellular interactions acting on the HSC-primed HECs.
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Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos
Yang Zeng,Chen Liu,Yandong Gong,Zhijie Bai,Siyuan Hou,Jian He,Zhilei Bian,Zongcheng Li,Yanli Ni,Jing Yan,Tao Huang,Hui Shi,Chunyu Ma,Xueying Chen,Jinyong Wang,Lihong Bian,Yu Lan,Bing Liu,Hongbo Hu +18 more
TL;DR: A single-cell transcriptional landscape of human early T lymphopoiesis is constructed by using cells from multiple hemogenic and hematopoietic sites spanning embryonic and fetal stages and identifies a distinct type of pre-thymic lymphoid progenitors in the aorta-gonad-mesonephros (AGM) region.
Journal ArticleDOI
Decoding Human Megakaryocyte Development.
Hongtao Wang,Jian He,Changlu Xu,Xiaoyuan Chen,Hua Yang,Shujuan Shi,Cuicui Liu,Yang Zeng,Dan Wu,Zhijie Bai,Mengge Wang,Yuqi Wen,Pei Su,Meijuan Xia,Baiming Huang,Chunyu Ma,Lihong Bian,Yu Lan,Tao Cheng,Lihong Shi,Bing Liu,Jiaxi Zhou +21 more
TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.
Journal ArticleDOI
Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs
Yibo Gan,Jian He,Jun Zhu,Zhengyang Xu,Zhong Wang,Jing Yan,Ou Hu,Zhijie Bai,Lin Chen,Yangli Xie,Min Jin,Shuo Huang,Bing Liu,Bing Liu,Bing Liu,Peng Liu +15 more
TL;DR: In this article, the transcriptomic landscape of 108 108 intervertebral disks (IVDs) was mapped using single-cell RNA sequencing of three main compartments from young and adult healthy IVDs, including the nucleus pulposus (NP), annulus fibrosus, and cartilage endplate (CEP).