J
Jian Jian Li
Researcher at University of California, Davis
Publications - 122
Citations - 8634
Jian Jian Li is an academic researcher from University of California, Davis. The author has contributed to research in topics: Radioresistance & Cancer. The author has an hindex of 46, co-authored 119 publications receiving 7577 citations. Previous affiliations of Jian Jian Li include University of California, Riverside & City of Hope National Medical Center.
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Journal ArticleDOI
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.
TL;DR: Evidence supporting the concept that perturbations in intracellular metabolic oxidation/reduction reactions contribute to the biological effects of radiation exposure is focused on as well as new concepts emerging from the field of free radical biology that may be relevant to future studies in radiobiology.
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Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.
Matthew R. Young,Jian Jian Li,Jian Jian Li,Mercedes Rincon,Richard A. Flavell,B. K. Sathyanarayana,Rosemarie Hunziker,Rosemarie Hunziker,Nancy H. Colburn +8 more
TL;DR: It is concluded that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention.
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The role of NF-κB in the regulation of cell stress responses
TL;DR: The purpose of this review is to briefly summarize the recent progress in the studies of the role of reactive oxygen species, cytokines and ionizing radiation in NF-kappaB activation.
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Manganese Superoxide Dismutase-Mediated Gene Expression in Radiation-Induced Adaptive Responses
Guozheng Guo,Yan Yan-Sanders,Beverly Lyn-Cook,Tieli Wang,Daniel Tamae,Julie Ogi,Alexander Khaletskiy,Zhongkui Li,Christine J. Weydert,Jeffrey Longmate,Ting Ting Huang,Douglas R. Spitz,Larry W. Oberley,Jian Jian Li +13 more
TL;DR: The hypothesis that NF-κB is capable of regulating the expression of MnSOD is supported, which in turn is able of increasing the expressionof genes that participate in radiation-induced adaptive responses.
Journal ArticleDOI
Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression
Zhaoqing Wang,Ming Fan,Demet Candas,Tie Qiao Zhang,Lili Qin,Angela Eldridge,Sebastian Wachsmann-Hogiu,Kazi M. Ahmed,Brett A. Chromy,Danupon Nantajit,Nadire Duru,Fuchu He,Min Chen,Toren Finkel,Lee S. Weinstein,Jian Jian Li +15 more
TL;DR: Cyclin B1/Cdk1-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.