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Jian Li

Bio: Jian Li is an academic researcher from Chongqing University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 133, co-authored 2863 publications receiving 87131 citations. Previous affiliations of Jian Li include Northeast Petroleum University & University of South Australia.


Papers
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Journal ArticleDOI
B. P. Abbott1, Richard J. Abbott, T. D. Abbott, Sheelu Abraham  +1145 moreInstitutions (8)
TL;DR: In this paper, the authors presented the results from three gravitational-wave searches for coalescing compact binaries with component masses above 1 Ma during the first and second observing runs of the advanced GW detector network.
Abstract: We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above 1 Ma™ during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (O1), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (O2), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star inspiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between 18.6-0.7+3.2 Mâ™ and 84.4-11.1+15.8 Mâ™ and range in distance between 320-110+120 and 2840-1360+1400 Mpc. No neutron star-black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of 110-3840 Gpc-3 y-1 for binary neutron stars and 9.7-101 Gpc-3 y-1 for binary black holes assuming fixed population distributions and determine a neutron star-black hole merger rate 90% upper limit of 610 Gpc-3 y-1.

2,336 citations

Journal ArticleDOI
TL;DR: It is shown that the waveform diversity offered by such a MIMO radar system enables significant superiority over its phased-array counterpart, including much improved parameter identifiability, direct applicability of adaptive techniques for parameter estimation, as well as superior flexibility of transmit beampattern designs.
Abstract: We have provided a review of some recent results on the emerging technology of MIMO radar with colocated antennas. We have shown that the waveform diversity offered by such a MIMO radar system enables significant superiority over its phased-array counterpart, including much improved parameter identifiability, direct applicability of adaptive techniques for parameter estimation, as well as superior flexibility of transmit beampattern designs. We hope that this overview of our recent results on the MIMO radar, along with the related results obtained by our colleagues, will stimulate the interest deserved by this topic in both academia and government agencies as well as industry.

2,163 citations

Journal ArticleDOI
TL;DR: Recent progress in understanding the complex chemistry, pharmacokinetics, and pharmacodynamics of colistin, the interplay between these three aspects, and their effect on the clinical use of this important antibiotic are summarized.
Abstract: Increasing multidrug resistance in Gram-negative bacteria, in particular Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, presents a critical problem. Limited therapeutic options have forced infectious disease clinicians and microbiologists to reappraise the clinical application of colistin, a polymyxin antibiotic discovered more than 50 years ago. We summarise recent progress in understanding the complex chemistry, pharmacokinetics, and pharmacodynamics of colistin, the interplay between these three aspects, and their effect on the clinical use of this important antibiotic. Recent clinical findings are reviewed, focusing on evaluation of efficacy, emerging resistance, potential toxicities, and combination therapy. In the battle against rapidly emerging bacterial resistance we can no longer rely entirely on the discovery of new antibiotics; we must also pursue rational approaches to the use of older antibiotics such as colistin.

1,190 citations

Journal ArticleDOI
14 Oct 2004-Neuron
TL;DR: A consistent neural response in the ventromedial prefrontal cortex was reported that correlated with subjects' behavioral preferences for Coke and Pepsi and brand knowledge for one of the drinks had a dramatic influence on expressed behavioral preferences and on the measured brain responses.

1,174 citations

Journal ArticleDOI
TL;DR: It is shown that a natural extension of the Capon beamformer to the case of uncertain steering vectors also belongs to the class of diagonal loading approaches, but the amount of diagonalloading can be precisely calculated based on the uncertainty set of the steering vector.
Abstract: The Capon (1969) beamformer has better resolution and much better interference rejection capability than the standard (data-independent) beamformer, provided that the array steering vector corresponding to the signal of interest (SOI) is accurately known. However, whenever the knowledge of the SOI steering vector is imprecise (as is often the case in practice), the performance of the Capon beamformer may become worse than that of the standard beamformer. Diagonal loading (including its extended versions) has been a popular approach to improve the robustness of the Capon beamformer. We show that a natural extension of the Capon beamformer to the case of uncertain steering vectors also belongs to the class of diagonal loading approaches, but the amount of diagonal loading can be precisely calculated based on the uncertainty set of the steering vector. The proposed robust Capon beamformer can be efficiently computed at a comparable cost with that of the standard Capon beamformer. Its excellent performance for SOI power estimation is demonstrated via a number of numerical examples.

1,113 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations