Jian Wang

TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Genotyping analysis showed that SNP identification had high accuracy and consistency, indicating the high sequence quality of this assembly, and the potential usefulness of next-generation sequencing technologies for personal genomics.

TL;DR: This work explored bird macroevolution using full genomes from 48 avian species representing all major extant clades to reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.

TL;DR: Positively selected and rapidly evolving genes in the yak lineage are found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism, which may have important implications for understanding adaptation to high altitude in other animal species and for Hypoxia-related diseases in humans.