J
Jian Yang
Researcher at Guangzhou Institutes of Biomedicine and Health
Publications - 10
Citations - 2199
Jian Yang is an academic researcher from Guangzhou Institutes of Biomedicine and Health. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 9, co-authored 10 publications receiving 1931 citations. Previous affiliations of Jian Yang include Wellcome Trust Centre for Stem Cell Research & Fudan University.
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Journal ArticleDOI
Capture of Authentic Embryonic Stem Cells from Rat Blastocysts
Mia Buehr,Stephen Meek,Kate Blair,Kate Blair,Jian Yang,Jian Yang,Janice Ure,José C. R. Silva,José C. R. Silva,Renee McLay,John Simon Hall,John Simon Hall,Qi-Long Ying,Austin Smith,Austin Smith +14 more
TL;DR: Derivation of germline-competent ES cells from the rat paves the way to targeted genetic manipulation in this valuable biomedical model species and will also provide a refined test-bed for functional evaluation of pluripotent stem cell-derived tissue repair and regeneration.
Journal ArticleDOI
Klf4 reverts developmentally programmed restriction of ground state pluripotency.
Ge Guo,Jian Yang,Jian Yang,Jennifer Nichols,Jennifer Nichols,John Simon Hall,John Simon Hall,Isobel Eyres,William Mansfield,Austin Smith,Austin Smith +10 more
TL;DR: In this article, a single reprogramming factor, Klf4, was introduced into EpiSCs, which activated expression of EScell-specific transcripts including endogenous klf4, and downstream markers of lineage specification.
Journal ArticleDOI
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
TL;DR: Findings indicate that Jak/Stat3 participate directly in molecular reprogramming and that activation of this pathway is a limiting component of pluripotency.
Journal ArticleDOI
Human naive epiblast cells possess unrestricted lineage potential.
Ge Guo,Ge Guo,Giuliano Giuseppe Stirparo,Giuliano Giuseppe Stirparo,Stanley E. Strawbridge,Daniel Spindlow,Jian Yang,James Clarke,Anish Dattani,Anish Dattani,Ayaka Yanagida,Ayaka Yanagida,Meng Amy Li,Sam Myers,Buse Nurten Özel,Jennifer Nichols,Austin Smith,Austin Smith +17 more
TL;DR: In this paper, it was shown that human naive embryonic stem cells readily make blastocyst trophectoderm and descendant trophoblast cell types, and they were induced rapidly and efficiently by inhibition of ERK/mitogenactivated protein kinase (MAPK) and Nodal signaling.
Journal ArticleDOI
A structurally defined mini-chromosome vector for the mouse germ line
Ming Hong Shen,P. Joseph Mee,Jennifer Nichols,Jian Yang,F. A. Brook,Richard L. Gardner,Austin Smith,William Brown +7 more
TL;DR: The structure and sequence organization of an engineered mammalian mini-chromosome, ST1, is determined and it is shown that it is stably maintained in vertebrate somatic cells and that it can be transmitted through the mouse germ line.