J
Jianfei Yang
Researcher at GlaxoSmithKline
Publications - 78
Citations - 5164
Jianfei Yang is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Computer science & T cell. The author has an hindex of 20, co-authored 39 publications receiving 4560 citations. Previous affiliations of Jianfei Yang include Niigata University & Washington University in St. Louis.
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Journal ArticleDOI
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
Maryam Afkarian,John R. Sedy,Jianfei Yang,N. G. Jacobson,Nezih Cereb,Soo Young Yang,Theresa L. Murphy,Kenneth M. Murphy +7 more
TL;DR: T-bet is induced by IFN-γ and STAT1 signaling during T cell activation and mediates STAT1-dependent processes of TH1 development, including the induction of IL-12Rβ2.
Journal ArticleDOI
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Norihiko Watanabe,Norihiko Watanabe,Maya Gavrieli,John R. Sedy,Jianfei Yang,Jianfei Yang,Francesca Fallarino,Susan K. Loftin,Michelle A. Hurchla,Natalie Zimmerman,Julia Sim,Xingxing Zang,Theresa L. Murphy,John H. Russell,James P. Allison,Kenneth M. Murphy +15 more
TL;DR: BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis.
Journal ArticleDOI
Signaling and Transcription in T Helper Development
Kenneth M. Murphy,Wenjun Ouyang,J. David Farrar,Jianfei Yang,Sheila Ranganath,Hélène Asnagli,Maryam Afkarian,Theresa L. Murphy +7 more
TL;DR: What has emerged is a richly detailed tapestry of signaling and transcription, controlling an important T cell developmental switch, particularly by the strongly polarizing cytokines IL-12 and IL-4.
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Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
Esen Sefik,Naama Geva-Zatorsky,Sungwhan F. Oh,Liza Konnikova,David Zemmour,Abigail Manson McGuire,Dalia Burzyn,Adriana Ortiz-Lopez,Mercedes Lobera,Jianfei Yang,Shomir Ghosh,Ashlee M. Earl,Scott B. Snapper,Ray Jupp,Dennis L. Kasper,Diane Mathis,Diane Mathis,Christophe Benoist,Christophe Benoist +18 more
TL;DR: It is reported that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses.
Journal ArticleDOI
Targeting Th17 cells in autoimmune diseases.
TL;DR: The rationale for targeting two checkpoints in the development and inflammatory function of Th17 cells, retinoid-related orphan receptor-γt (RORγt) and IL-23, and the development of both RORγt small molecule inhibitors andIL-23 neutralizing antibodies is discussed.