J
Jiang Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 44
Citations - 4314
Jiang Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Chromatin remodeling & Sonic hedgehog. The author has an hindex of 23, co-authored 43 publications receiving 3860 citations. Previous affiliations of Jiang Wu include Howard Hughes Medical Institute & Stanford University.
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Journal ArticleDOI
An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development
Julie Lessard,Jiang Wu,Jeffrey A. Ranish,Mimi Wan,Monte M. Winslow,Brett T. Staahl,Hai Wu,Ruedi Aebersold,Isabella A. Graef,Gerald R. Crabtree +9 more
TL;DR: It is suggested that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits by preventing the subunit switch impairs neuronal differentiation.
Journal ArticleDOI
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Lena Ho,Jehnna L. Ronan,Jiang Wu,Brett T. Staahl,Lei Chen,Ann Kuo,Julie A. Lessard,Julie A. Lessard,Alexey I. Nesvizhskii,Jeff Ranish,Gerald R. Crabtree +10 more
TL;DR: It is shown that BAF complexes are required for the self-renewal and pluripotency of mouse ES cells but not for the proliferation of fibroblasts or other cells, suggesting that esBAF complexes are specialized to interact with ES cell-specific regulators, providing a potential explanation for the requirement of BAF complex in pluripOTency.
Journal ArticleDOI
Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes
Jiang Wu,Julie Lessard,Ivan A. Olave,Zilong Qiu,Anirvan Ghosh,Isabella A. Graef,Gerald R. Crabtree,Gerald R. Crabtree +7 more
TL;DR: These studies suggest that the genes encoding the individual subunits of BAF complexes function like letters in a ten-letter word to produce biologically specific meanings (in this case dendritic outgrowth) by combinatorial assembly of their products.
Journal ArticleDOI
Understanding the words of chromatin regulation.
TL;DR: Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histone modifications.
Journal ArticleDOI
Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
Yang Yu,Yang Yu,Ying Chen,Bong-Woo Kim,Bong-Woo Kim,Haibo Wang,Chuntao Zhao,Xuelian He,Xuelian He,Lei Liu,Lei Liu,Wei Liu,Wei Liu,Lai Man N. Wu,Meng Mao,Jonah R. Chan,Jiang Wu,Q. Richard Lu +17 more
TL;DR: Regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS.