J
Jianhua Sui
Researcher at Harvard University
Publications - 65
Citations - 13865
Jianhua Sui is an academic researcher from Harvard University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 33, co-authored 56 publications receiving 11867 citations. Previous affiliations of Jianhua Sui include Peking Union Medical College & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Huan Yan,Guocai Zhong,Guangwei Xu,Wenhui He,Zhiyi Jing,Zhenchao Gao,Yi Huang,Yonghe Qi,Bo Peng,Haimin Wang,Liran Fu,Mei Song,Pan Chen,Wenqing Gao,Bijie Ren,Yinyan Sun,Tao Cai,Xiaofeng Feng,Jianhua Sui,Wenhui Li +19 more
TL;DR: It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
Journal ArticleDOI
Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses
Jianhua Sui,William C. Hwang,Sandra Elizabeth Pérez,Ge Wei,Daniel Aird,Li-Mei Chen,Eugenio Santelli,Boguslaw Stec,Greg Cadwell,Maryam Ali,Hongquan Wan,Akikazu Murakami,Anuradha Yammanuru,Thomas Han,Nancy J. Cox,Laurie A. Bankston,Ruben O. Donis,Robert C. Liddington,Wayne A. Marasco +18 more
TL;DR: The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion, and suggests that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
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Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
Wenhui Li,Chengsheng Zhang,Chengsheng Zhang,Jianhua Sui,Jens H. Kuhn,Jens H. Kuhn,Michael Moore,Shiwen Luo,Swee-Kee Wong,I-Chueh Huang,Keming Xu,Natalya Vasilieva,Akikazu Murakami,Yaqing He,Wayne A. Marasco,Yi Guan,Hyeryun Choe,Michael Farzan +17 more
TL;DR: Comparisons of S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and during the much less severe 2003–2004 outbreak, and from palm civets, provide insight into the severity of the 2002‐ 2003 SARS epidemic.
Journal ArticleDOI
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
Jens Wrammert,Dimitrios G. Koutsonanos,Gui-Mei Li,Srilatha Edupuganti,Jianhua Sui,Michael Morrissey,Megan McCausland,Ioanna Skountzou,Mady Hornig,W. Ian Lipkin,Aneesh K. Mehta,Behzad Razavi,Carlos del Rio,Nai-Ying Zheng,Jane-Hwei Lee,Min Huang,Zahida Ali,Kaval Kaur,Sarah F. Andrews,Rama Rao Amara,Youliang Wang,Suman R. Das,Christopher D. O'Donnell,J W Yewdell,Kanta Subbarao,Wayne A. Marasco,Mark J. Mulligan,Richard W. Compans,Rafi Ahmed,Patrick C. Wilson +29 more
TL;DR: Although scarce after annual influenza vaccination, B cells producing antibodies capable of neutralizing multiple influenza strains are abundant in humans infected with pandemic 2009 H1N1 influenza.