J
Jianjun Cheng
Researcher at University of Illinois at Urbana–Champaign
Publications - 404
Citations - 23226
Jianjun Cheng is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Medicine & Polymerization. The author has an hindex of 71, co-authored 313 publications receiving 19457 citations. Previous affiliations of Jianjun Cheng include ShanghaiTech University & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Omid C. Farokhzad,Jianjun Cheng,Jianjun Cheng,Benjamin A. Teply,Ines Sherifi,Sangyong Jon,Philip W. Kantoff,Jerome P. Richie,Robert Langer,Robert Langer +9 more
TL;DR: The potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application is demonstrated and remarkable efficacy and reduced toxicity as measured by mean body weight loss (BWL) in vivo are demonstrated.
Journal ArticleDOI
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
Jianjun Cheng,Benjamin A. Teply,Benjamin A. Teply,Ines Sherifi,Ines Sherifi,Josephine Sung,Gaurav Luther,Frank X. Gu,Etgar Levy-Nissenbaum,Etgar Levy-Nissenbaum,Aleksandar Filip Radovic-Moreno,Robert Langer,Omid C. Farokhzad,Omid C. Farokhzad +13 more
TL;DR: It is found that NP mean volumetric size correlates linearly with polymer concentration for NPs between 70 and 250 nm in diameter and the ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies.
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Bioresorbable silicon electronic sensors for the brain
Seung-Kyun Kang,Rory K.J. Murphy,Suk Won Hwang,Seungmin Lee,Daniel V. Harburg,Neil A. Krueger,Jiho Shin,Paul Gamble,Huanyu Cheng,Sooyoun Yu,Zhuangjian Liu,Jordan G. McCall,Manu Stephen,Hanze Ying,Jeonghyun Kim,Gayoung Park,R. Chad Webb,Chi Hwan Lee,Sangjin Chung,Dae Seung Wie,Amit D. Gujar,Bharat Vemulapalli,Albert H. Kim,Kyung Mi Lee,Jianjun Cheng,Younggang Huang,Sang Hoon Lee,Paul V. Braun,Wilson Z. Ray,John A. Rogers +29 more
TL;DR: Material, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction.
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Dynamic urea bond for the design of reversible and self-healing polymers
TL;DR: The rational design of hindered urea bonds are reported and the use of them to make polyureas and poly(urethane-ureas) capable of catalyst-free dynamic property change and autonomous repairing at low temperature is reported.
Journal ArticleDOI
Investigating the optimal size of anticancer nanomedicine
Li Tang,Xujuan Yang,Qian Yin,Kaimin Cai,Hua Wang,Isthier Chaudhury,Catherine Yao,Qin Zhou,Mincheol Kwon,James A. Hartman,Iwona T. Dobrucki,Lawrence W. Dobrucki,Luke B. Borst,Stéphane Lezmi,William G. Helferich,Andrew L. Ferguson,Timothy M. Fan,Jianjun Cheng +17 more
TL;DR: Among the three NCs investigated, the 50-nm NC shows the highest tumor tissue retention integrated over time, which is the collective outcome of deep tumor tissue penetration and efficient cancer cell internalization as well as slow tumor clearance, and thus, the highest efficacy against both primary and metastatic tumors in vivo.