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Author

Jiann-Kuan Luo

Other affiliations: Nagasaki University
Bio: Jiann-Kuan Luo is an academic researcher from University of South Florida. The author has contributed to research in topics: Quinoline & Ring (chemistry). The author has an hindex of 12, co-authored 54 publications receiving 342 citations. Previous affiliations of Jiann-Kuan Luo include Nagasaki University.


Papers
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Journal ArticleDOI
TL;DR: In this article, a modification of the IDR-HMQC-TOCSY method is also demonstrated which is capable of fully suppressing direct responses (SDR) without resorting to the timing of the onset of decoupling as in the original report of the HMQC TOCSY experiment.

23 citations

Journal ArticleDOI
TL;DR: In this paper, the synthesis of two previously unknown heterocyclic ring systems, namely, thieno[3′,2′:4,5]thieno [2,3-c]-quinoline and thienon[2′,3′: 4,5], was reported, which were assembled by photocyclization of the appropriate anilides.

19 citations

Journal ArticleDOI
TL;DR: In this article, the synthesis of two polycyclic heterocyclic ring systems via photocyclization is reported, and the total assignment of their 1H- and 13C-nmr spectra is determined by utilizing two-dimensional nmr spectroscopic methods.

17 citations

Journal ArticleDOI
TL;DR: In this paper, the structural confirmation of 3-chloro-N-(3-phenanthryl)thieno[2,3-b]thiophene-2-carboxamide was achieved by the total assignment of its 1H and 13C nmr spectra by the concerted utilization of two-dimensional nm r spectroscopic methods.

17 citations


Cited by
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Journal ArticleDOI

987 citations

Patent
27 Mar 2015
TL;DR: In this paper, novel tricarbazole compounds with appropriate HOMO and LUMO energies can be obtained for use as materials in a secondary hole transport layer, by appropriately selecting the nature of the tricarazole substituents.
Abstract: Novel tricarbazole compounds are provided. By appropriately selecting the nature of the tricarbazole substituents, compounds with appropriate HOMO and LUMO energies can be obtained for use as materials in a secondary hole transport layer.

445 citations

Patent
Prabha N. Ibrahim1, Wayne Spevak1, Hanna Cho1, Songyuan Shi1, Chao Zhang1, Ying Zhang1 
04 Nov 2010
TL;DR: In this paper, compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described to treat diseases and conditions, including diseases associated with activity of B-Raf V600E mutant protein kinase.
Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.

322 citations

Journal ArticleDOI
TL;DR: The practical syntheses of 1,14-diaza[5]helicene (1), 1-aza[6]he Licene (2), and 2-aza [6] helicenes (3) are reported, which have succeeded in resolving racemates of 2 and 3 into their enantiomers, assigning their absolute configuration, determining the energy barriers to racemization, and obtaining Xray structures of their corresponding silver complexes.
Abstract: Helicenes have attracted attention as unique inherently chiral three-dimensional aromatic compounds for several decades. Despite significant recent progress in the synthesis and applications of carbohelicenes and thiaheterohelicenes, the potential of the aza analogues with a pyridine unit (pyridohelicenes) have not been explored. There are only scattered examples of the preparation of pyridohelicenes, but with no general synthetic methodology, since the photochemical approach can fail with pyridohelicenes while non-photochemical alternatives can be difficult to adapt to the synthesis of N-heteroaromatic compounds. The properties and chemical behavior of pyridohelicenes are practically unknown apart from their basicities and the self-assembly of certain derivatives. Nevertheless, promising applications of pyridohelicenes in various branches of chemistry and material science might be envisaged and, therefore, further research in the field is required. Recently, we observed remarkably high proton affinities of pyridohelicene derivatives, as measured by mass spectrometric techniques. In the gas phase, helically chiral 1aza[6]helicene (2, Scheme 1), for example, exhibits a comparable proton affinity (1000 kJmol ) to 4-(dimethylamino)pyridine (DMAP, 997 kJmol ). Herein, we report the practical syntheses of 1,14-diaza[5]helicene (1), 1-aza[6]helicene (2), and 2-aza[6]helicene (3). Moreover, we have succeeded in resolving racemates of 2 and 3 into their enantiomers, assigning their absolute configuration, determining the energy barriers to racemization, and obtaining Xray structures of their corresponding silver complexes. The strategy for the preparation of 1–3 relies on a [2+2+2] cyclotrimerization of an aromatic triyne in the presence of a Co catalyst to build the helical scaffold. We have already proven that such a methodology is robust and reliable for the preparation of helicenes and their analogues. Thus, the straightforward synthesis of 1 started from the readily accessible bromopyridine 4, which was treated with lithiated 1-(triisopropylsilyl)-1-propyne to yield 5 which contained an attached alkyne side arm (Scheme 2). SonogaScheme 1.

145 citations