Jiansheng Wu

TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.

TL;DR: The discovery of a small-molecule binding pocket on Ras with functional significance provides a new direction in the search of therapeutically effective inhibitors of the Ras oncoprotein.

TL;DR: It is shown that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS), and Knockin mice expressing B AP1 with a 3xFlag tag revealed that BAP1 interacts with host cell factor–1, O-linked N-acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL

TL;DR: It is found that the ERBB3 mutants transformed colonic and breast epithelial cells in a ligand-independent manner, however, the mutant ER BB3 oncogenic activity was dependent on kinase-active ERBB2.

TL;DR: The presence of frequent mutations in p85alpha in colon cancer are shown, a majority of which occurs in the inter-Src homology-2 (iSH2) domain, to promote cell survival, AKT activation, anchorage-independent cell growth, and oncogenesis in a p110-dependent manner.