Jianxin Ma

Bio: Jianxin Ma is an academic researcher from University of Science and Technology Beijing. The author has contributed to research in topics: Biosensor & Nanotechnology. The author has co-authored 2 publications. Previous affiliations of Jianxin Ma include Shenzhen University.

Luminescent Covalent Organic Frameworks for Biosensing and Bioimaging Applications.

Abstract: Luminescent covalent organic frameworks (LCOFs) have attracted significant attention due to their tunability of structures and photophysical properties at molecular level. LCOFs are built to highly ordered and periodic 2D or 3D framework structures through covalently assembling with various luminophore building blocks. Recently, the advantages of LCOFs including predesigned properties of structure, unique photoluminescence, hypotoxicity and good biocompatibility and tumor penetration, broaden their applications in biorelated fields, such as biosensing, bioimaging, and drug delivery. A specific review that analyses the advances of LCOFs in the field of biosensing and bioimaging is thus urged to emerge. Here the construction of LCOFs is reviewed first. The synthetic chemistry of LCOFs highlights the key role of chemical linkages, which not only concrete the building blocks but also affect the optical properties and even can act as the responsive sites for potential sensing applications. How to brighten LCOFs are clarified through description of structure managements. The ability to utilize the luminescence of LCOFs for applications in biosensing and bioimaging is discussed using state-of-the-art examples of varied practical goals. A prospect finally addresses opportunities and challenges the development of LCOFs facing from chemistry, physics to the applications, according to their current progress.

Rational Design of ZIF-8 for Constructing Luminescent Biosensors with Glucose Oxidase and AIE-Type Gold Nanoclusters.

Abstract: The development of modern technologies has acclimatized biosensors to complicated applicable scenarios with integrated properties as a whole instead of the pursuit of a single-point breakthrough. Here, we targeted a few concerns in the development of enzyme-based biosensors, including stability, analyte enrichment, and signal transduction, and developed a general biosensing model utilizing enzymes, aggregation-induced emission (AIE) luminogens, and stimuli-responsive framework materials as the units. We propose such proof-of-concept of glucose biosensors by coencapsulating glucose oxidase and AIE-type gold nanoclusters into acid-sensitive zeolite imidazolate framework (ZIF)-8 nanocrystals. The acid-activated degradation of ZIF-8 bridges the molecular signals produced by the enzyme-catalytic reaction of glucose and the photon signals generated by ZIF-8-induced AIE effects of gold nanoclusters, resulting in the "turn-off" model nanoprobes for glucose detection with high selectivity. After embedding the nanoprobes into hollow-out tapes, the formed paper biosensors can conveniently detect glucose with the help of a smartphone.

Portable point-of-care diagnostic devices: an updated review.

Abstract: The global pandemic caused by the SARS-CoV-2 (COVID) virus indiscriminately impacted people worldwide with unquantifiable and severe impacts on all aspects of our lives, regardless of socioeconomic status. The pandemic brought to light the very real possibility of pathogens changing and shaping the way we live, and our lack of preparedness to deal with viral/bacterial outbreaks. Importantly, the quick detection of pathogens can help prevent and control the spread of disease, making the importance of diagnostic techniques undeniable. Point-of-care diagnostics started as a supplement to standard lab-based diagnostics, and are gradually becoming mainstream. Because of this, and their importance in detecting pathogens (especially in the developing world), their development has accelerated at an unprecedented rate. In this review, we highlight some important and recent examples of point-of-care diagnostics for detecting nucleic acids, proteins, bacteria, and other biomarkers, with the intent of making apparent their positive impact on society and human health.

Metalated covalent organic frameworks: from synthetic strategies to diverse applications.

Abstract: Covalent organic frameworks (COFs) are a class of organic crystalline porous materials discovered in the early 21st century that have become an attractive class of emerging materials due to their high crystallinity, intrinsic porosity, structural regularity, diverse functionality, design flexibility, and outstanding stability. However, many chemical and physical properties strongly depend on the presence of metal ions in materials for advanced applications, but metal-free COFs do not have these properties and are therefore excluded from such applications. Metalated COFs formed by combining COFs with metal ions, while retaining the advantages of COFs, have additional intriguing properties and applications, and have attracted considerable attention over the past decade. This review presents all aspects of metalated COFs, from synthetic strategies to various applications, in the hope of promoting the continued development of this young field.

Recent Advances in Luminescent Hydrogen‐Bonded Organic Frameworks: Structures, Photophysical Properties, Applications

Abstract: Hydrogen‐bonded organic frameworks (HOFs) have aroused interest due to their applications in gas storage and separation and proton conduction. Much effort has been focused on developing stable HOFs with permanent porosity. Recently, more attention has been paid to the development of luminescent HOFs. At present, a systematic study on luminescent HOFs is lacking. Here, recent advances in luminescent HOFs are highlighted. The construction of luminescent HOFs, luminescent properties of HOFs, and corresponding applications are discussed in detail. According to luminescent properties, luminescent HOFs can be divided into fluorescent HOFs and room‐temperature phosphorescent HOFs. In addition, HOFs with color‐tunable luminescence, stimuli‐responsive luminescence, or mechanoluminescence are also introduced at great length. These distinctive features endow HOFs with wide applications in chemical sensing, microlasers, stimuli‐responsive sensing, oxygen sensing, data encryption, and so on. This review not only provides the basic principle of designing luminescent HOFs but also points out the research perspectives of luminescent HOFs in the future. This review lays the foundation for developing luminescent HOFs, thus broadening the applications of HOFs and enriching luminescent porous materials.