Jiawei Wang

TL;DR: A summary-statistic-based testing framework that combines multiple single-tissue associations into a powerful metric to quantify the overall gene–trait association is described and applied to multiple genome-wide-association results.

TL;DR: In this article, the authors found enrichment of TFH cell transcriptional signature correlates with GC B cell signature and with prolonged survival in individuals with lung adenocarcinoma (LUAD).

TL;DR: In this paper, differential gene expression and network analyses of four prefrontal cortex subregions from postmortem tissue of people with PTSD demonstrate extensive remodeling of the transcriptomic landscape, and a highly connected downregulated set of interneuron transcripts is present in the most significant gene network associated with PTSD.

TL;DR: In this article, the authors show that Stem-like TCF1+ CD8+ T cells are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy.

TL;DR: The existence of a previously unexplored universe of genotoxic small molecules from the microbiome that may affect host biology in homeostasis and disease is revealed.