Jiaying Huang

Bio: Jiaying Huang is an academic researcher from Nanchang University. The author has contributed to research in topics: Adsorption & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 111 citations.

Nanoformulation of Paclitaxel: Exploring the Cyclodextrin / PLGA Nano Delivery Carrier to Slow Down Paclitaxel Release, Enhance Accumulation in Vivo

Abstract: Background: Improving the aggregation and penetration in tumor sites increases the anti-tumor efficacy of nanomedicine. In the current study, we designed cyclodextrin modified PLGA nanoparticles loaded with paclitaxel to elevate the accumulation and prolong circulation of chemotherapy drugs in vivo. Methods: The PLGA nanoparticles loaded with paclitaxel (PTX PLGA NPs) and cyclodextrin (CD) modified PLGA nanoparticles loaded with paclitaxel (PTX PLGA/CD NPs) were prepared using the emulsification solvent evaporation method. The nanoparticles were characterized by particle size, zeta potential, encapsulation efficiency, infrared spectroscopy analysis and X-Ray diffraction (XRD). Then, drug release of the nanoparticles was evaluated via reverse dialysis method in vitro. Finally, the in vivo distribution fate and pharmacokinetic characteristics of the nanoparticles were assessed in mice and rats. Results: The average particle size, zeta potential, and encapsulation efficiency of PTX PLGA NPs were (163.57±2.07) nm, - (20.53±2.79) mV and (60.44±6.80)%. The average particle size, zeta potential, and encapsulation efficiency of PTX PLGA/CD NPs were (148.57±1.66) nm, - (11.42±0.84) mV and (85.70±2.06)%. In vitro release studies showed that PTX PLGA/CD NPs were released more slowly compared to PTX PLGA NPs under normal blood pH conditions, while PTX PLGA/CD NPs were released more completely under tumor site pH conditions. The modified PLGA nanocarrier (PLGA/CD NPs) increased drug residence time and accumulation than the plain PLGA nanocarrier (PLGA NPs) in vivo distribution. In addition, the elimination half-life, area under the drug-time curve, and maximum blood concentration of the nanoparticle group were higher than those of Taxol®, especially the PTX PLGA/CD NPs group, which was significantly different from Taxol® and plain nanoparticle groups (p<0.001). Conclusions: The 2-HP-β-CD modified PLGA nanoparticles prolonged circulation time and accumulation of the chemotherapy drug paclitaxel in vivo.

Ferrite nanoparticles: Synthesis, characterisation and applications in electronic device

Abstract: Ferrite nanoparticles (FNPs) have attracted a great interest due to their wide applications in several areas such as biomedical, wastewater treatment, catalyst and electronic device. This review focuses on the synthesis, characterisation and application of FNPs in electronic device with more emphasis on the recently published works. The most commonly used synthesis techniques along with their advantages and limitations are discussed. The available characterisation techniques and their application in electronic materials such as sensors and biosensors, energy storage, microwave device, electromagnetic interference shielding and high-density recording media are briefly reviewed.

Current methods for synthesis of magnetic nanoparticles

Abstract: The synthesis of different kinds of magnetic nanoparticles (MNPs) has attracted much attention. During the last few years, a large portion of the articles published about MNPs have described efficient routes to attain shape-controlled and highly stable MNPs with narrow size distribution. In this review, we have reported several popular methods including co-precipitation, microemulsion, thermal decomposition, solvothermal, sonochemical, microwave-assisted, chemical vapor deposition, combustion, carbon arc, and laser pyrolysis, for the synthesis of magnetic nanoparticles.

Magnetic composite an environmental super adsorbent for dye sequestration – A review

Abstract: Adsorption is the most extensively used technique for dye sequestration. Magnetic separation of toxic pollutant is becoming a potential method in waste water purification and found to have predominant significance in the removal of dyes more effectively compared to conventional method of treatments. Numerous natural and synthetic adsorbents were used, out of which magnetic composites (MCs) and magnetic nanocomposites (MNCs) have gained much attention presently in the removal of dyes from aqueous solution. Abundant references are existing pertaining to synthesis of various magnetic composites and its application in adsorption of dyes. This report displays the exploitation of MCs and MNCs for adsorption of dyes, hazards posed by dyes, sorption mechanism, preparation methods, magnetic behavior and characteristics of magnetized particles with the relevant literature on the basic principle of adsorption using MCs and MNCs for separation of dyes under optimum physicochemical condition. Adsorption reaction model, diffusion model and isotherms which facilitate in understanding the reaction mechanism between adsorbent and adsorbate are concisely discussed.

Influence of stirring velocity on the synthesis of magnetite nanoparticles (Fe3O4) by the co-precipitation method

Abstract: Superparamagnetic magnetite nanoparticles (mean diameter ∼10 nm) were synthesized using the co-precipitation route from Fe2+/Fe3+ in aqueous solutions (molar ratio 1:2) by adding a base under mechanical stirring at 10,000 rpm. This stirring velocity was found to be suitable for obtaining nanoparticles of this mean size, and a decrease in stirring velocity resulted in a larger size (∼19 nm) and a wider size distribution. At 18,000 rpm, in addition to magnetite, goethite is also synthesized in the form of nanoparticles and nanorods are found. At higher stirring velocities (25,000 rpm), the solution's core temperature increased from 20° to 37 °C, generating a mixture of non-magnetic iron compounds.