Jie Cao

TL;DR: It is reported that increased expression of p28GANK (Gankyrin, PSMD10, or p28) in human HCC predicts poor survival and disease recurrence after surgery, and the combination of these two parameters is a more powerful predictor of poor prognosis.

TL;DR: It is reported that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes, and this results present a novel mechanism involving modulation of ATG7 by PS MD10 in sustainingAutophagy, promoting HCC cell survival against starvation or chemotherapy.

TL;DR: In this paper, the authors quantified levels of p28 GANK (Gankyrin), OV6, and Oct4 in 130 human hepatocellular carcinoma (HCC) samples using immunohistochemistry.

TL;DR: Results indicate that p28GANK inhibits ER stress-induced apoptosis in HCC cells, at least in part, by enhancing the adaptive response and GRP78 expression, and it is proposed that p 28GANK has potential implications for HCC progression under the ER stress conditions.

TL;DR: Results suggest that the selected motif SPQYWTGPA should be a mimotope of HCV E2 to bind to hCD81 molecules, and cast new light on developing HCV receptor antagonists.