Showing papers by "Jie Zhang published in 1994"
TL;DR: Nitric oxide stimulated ADP-ribosylation of PARS in rat brain and blocked N-methyl-D-aspartate- and NO-mediated neurotoxicity with relative potencies paralleling their ability to inhibit PARS.
Abstract: Poly(adenosine 5'-diphosphoribose) synthetase (PARS) is a nuclear enzyme which, when activated by DNA strand breaks, adds up to 100 adenosine 5'-diphosphoribose (ADP-ribose) units to nuclear proteins such as histones and PARS itself. This activation can lead to cell death through depletion of beta-nicotinamide adenine dinucleotide (the source of ADP-ribose) and adenosine triphosphate. Nitric oxide (NO) stimulated ADP-ribosylation of PARS in rat brain. Benzamide and other derivatives, which inhibit PARS, blocked N-methyl-D-aspartate- and NO-mediated neurotoxicity with relative potencies paralleling their ability to inhibit PARS. Thus, NO appeared to elicit neurotoxicity by activating PARS.
1,155 citations
TL;DR: A variety of mechanisms have been proposed for NO neurotoxicity, including inhibition of mitochondrial enzymes such as cis-aconitase, inhibition of the mitochondria1 electron transport chain, ribonucleotide reductase, DNA damage, mono-adenosine diphosphate (ADP)-ribosylation, and S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase.
Abstract: Publisher Summary A variety of mechanisms have been proposed for NO neurotoxicity, including inhibition of mitochondrial enzymes such as cis-aconitase, inhibition of the mitochondria1 electron transport chain, inhibition of ribonucleotide reductase, DNA damage, mono-adenosine diphosphate (ADP)-ribosylation, and S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase. Excessive stimulation of N-methyl-D-aspartate (NMDA) by glutamate leads to excess production of NO, which is toxic to neurons under a variety of experimental paradigms and pathological conditions. When excessive amounts of NO are formed in response to the actions of the excitatory neurotransmitter, glutamate, acting at NMDA receptors, NO mediates components of neuronal killing NMDA toxicity acting via NO may account for neural damage associated with acquired immunodeficiency syndrome (AIDS) dementia as well as neural damage in cerebral infarction. Strategies aimed at decreasing the formation of NO or identifying targets of NO'S action may have clinical relevance for the development of agents which can prevent or reverse these degenerative disorders.
83 citations
TL;DR: In this article, measurements of the inclusive cross-sections for Λ and Λ production in hadronic decays of the Z are presented together with measurements of two-particle correlations within pairs of Λ, and the results are compared with predictions from the hadronization models Jetset, based on string fragmentation, and Herwig based on cluster decays.
Abstract: Measurements of the inclusive cross-sections forK
0 and Λ production in hadronic decays of the Z are presented together with measurements of two-particle correlations within pairs of Λ andK
0. The results are compared with predictions from the hadronization models Jetset, based on string fragmentation, and Herwig, based on cluster decays. TheK
0 spectrum is found to be harder than predicted by both models, while the Λ spectrum is softer than predicted. The correlation measurements are all reproduced well by Jetset, while Herwig misses some of the qualitative features and overestimates the size of the
$$\Lambda \bar \Lambda $$
correlation. Finally, the possibility of Bose-Einstein correlation in theK
0
K
0
system is discussed.
30 citations
TL;DR: In this paper, the B 0 B 0 oscillation was studied using almost a million hadronic Z decays collected by the ALEPH experiment at LEP, where events were selected with two leptons present, on opposite sides of the event and with high transverse momentum.
29 citations
27 citations
TL;DR: In this article, the ALEPH detector at LEP measured correlations between the decay products of the τ+ and τ− produced in the decay of the Z have been measured and the measured values are ζπ = −0.95 ± 0.04.
25 citations
24 citations
TL;DR: In this paper, a sample of about 75000 τ decays identified with the ALEPH detector, K 0 production in 1-prong hadronic decays was investigated by tagging the K L 0 component in a hadronic calorimeter.
14 citations
TL;DR: In this paper, a new measurement of the forward-backward asymmetry in Z --> bbBAR decays is presented, where the b quark charge and direction are reconstructed with a hemisphere charge algorithm.
13 citations
TL;DR: In this paper, the authors investigate alpha-cluster geometries and collectivity in the Bloch-Brink alpha clustering model and find that the geometrical arrangements of the alpha-Clusters can be derived from relaxed atomic and metallic ''cluster'' structures.
7 citations
TL;DR: In this paper, the α-transfer reaction 12 C(12 C, 16 O∗) 8 Be has been studied at E lab = 120 MeV, and the 12 Cα angular correlations from the decay of 16 O ∗ have been used to make spin assignments for many high-spin states at high excitation in 16 O.
TL;DR: In this article, the authors derived geometric derivations of the second constant of motion in the regime of planar motion of a billiard in an elliptic cavity, and also derived a number of other results geometrically.
Abstract: The product of the focal angular momenta of an elliptic billiard is a conserved quantity, which is known as the second constant of motion. Its value can be derived both dynamically and geometrically. We give geometric derivations of the second constant of motion in the regime of planar motion of a billiard in an elliptic cavity. We also derive a number of other results geometrically.
TL;DR: In this article, the α-transfer reaction 12C(16O, 20Ne∗)8Be has been studied at Elab = 150 MeV and the 16Oα angular correlations from the decay of 20Ne ∗ have been measured and analysed with a strong absorption model to make spin assignments for many high-spin states at high excitation in 20Ne.
Journal Article•