Showing papers by "Jie Zhang published in 1999"
TL;DR: PARP inhibitors could provide novel therapeutic approaches in a wide range of clinical disorders and afford dramatic protection from tissue damage in conditions as diverse as focal cerebral ischaemia, myocardial infarction and toxin-induced diabetes.
515 citations
TL;DR: The findings indicate that DPQ exerts its neuroprotective effects in vivo by PARP inhibition and that PARP inhibitors may be effective for treating ischemic stroke, even when the treatment is initiated after the onset of ischemia.
170 citations
TL;DR: In vitro activity of voriconazole compared to those of fluconazole and itraconazole against 566 clinical isolates of Cryptococcus neoformans from Africa and the United States suggest that it may be useful in the treatment of cryptococcosis.
Abstract: We investigated the in vitro activity of voriconazole compared to those of fluconazole and itraconazole against 566 clinical isolates of Cryptococcus neoformans from Africa (164) and the United States (402). Isolates were obtained from cerebrospinal fluid (362), blood (139), and miscellaneous sites (65). Voriconazole (MIC at which 90% of the isolates are inhibited [MIC90], 0.12 to 0.25 microg/ml) was more active than either itraconazole (MIC90, 0.5 microg/ml) or fluconazole (MIC90, 8.0 to 16 microg/ml) against both African and U. S. isolates. Isolates inhibited by >/=16 microg of fluconazole per ml were almost all (99%) inhibited by
120 citations
TL;DR: Data indicate that SFV-IL12 inhibits tumor growth through its antiangiogenic activity, demonstrated for the first time in vivo by DUS, and suggest that the SFV vector may be a novel valuable tool in tumor gene transfer.
Abstract: To elucidate further the potential of a Semliki Forest virus (SFV) vector in vivo for gene therapy, we constructed a vector, SFV-IL12, to transfer murine IL-12 genes into tumors. A single intratumoral injection of established B16 murine melanoma with SFV-IL12 resulted in a significant inhibition of tumor growth, while injection with SFV-LacZ had no effect. This antitumoral activity correlated with an increase of IFN gamma production, MIG and IP-10 mRNA expression, both at the tumor site and at the periphery. In contrast, no increase in CTL- or NK cell-mediated cytotoxic response could be detected, ruling out the involvement of T and NK cell cytotoxicity. To determine how the transfer to IL-12 genes induced tumor regression, the antiangiogenic-activity of SFV-IL12 was investigated using Doppler ultrasonography (DUS). SFV-IL12 inhibited in situ neovascularization within the tumor, without affecting the resistance index of pre-existing intratumoral blood flows. In addition, histological analysis of SFV-IL12-treated tumors showed massive tumor necrosis induced by SFV-IL12 treatment. These data indicate that SFV-IL12 inhibits tumor growth through its antiangiogenic activity, demonstrated for the first time in vivo by DUS, and suggest that the SFV vector may be a novel valuable tool in tumor gene transfer.
110 citations
Hirosaki University1, Saitama University2, Tibet University3, Academia Sinica4, Southwest Jiaotong University5, Kanagawa University6, Utsunomiya University7, University of Tokyo8, Konan University9, Shibaura Institute of Technology10, Yunnan University11, Yokohama National University12, Shonan Institute of Technology13
TL;DR: In this article, the lowest energy air shower array at Yangbajing (4300 m above sea level) was used to detect the Crab Nebula in multi-TeV γ-rays and a signal was detected at the 5.5 σ level.
Abstract: The Tibet experiment, operating at Yangbajing (4300 m above sea level), is the lowest energy air shower array, and the new high-density array constructed in 1996 is sensitive to γ-ray air showers at energies as low as 3 TeV. With this new array, the Crab Nebula was observed in multi-TeV γ-rays and a signal was detected at the 5.5 σ level. We also obtained the energy spectrum of γ-rays in the energy region above 3 TeV which partially overlaps those observed with imaging atmospheric Cerenkov telescopes. The Crab spectrum observed in this energy region can be represented by the power-law fit dJ(E)/dE = (4.61 ± 0.90) × 10-12(E/3 TeV)-2.62±0.17 cm-2 s-1 TeV-1. This is the first observation of γ-ray signals from point sources with a conventional air shower array using scintillation detectors.
60 citations
TL;DR: In this paper, the γ∗γ interactions to hadronic final states where one scattered electron or positron is detected in the electromagnetic calorimeters have been studied in the LEP 1 data taken by ALEPH from 1991 to 1995.
28 citations
TL;DR: In this paper, the scalar partners of quarks and leptons predicted in supersymmetric models were found in the decay channels, and improved mass lower limits were obtained in the framework of the Minimal Supersymmetric Standard Model.
25 citations
TL;DR: In this article, the e+e−→ZZ cross section at s =182.7 and 188.6 GeV has been measured using the ALEPH detector using a cut-based analysis.
21 citations
TL;DR: In this paper, the production of W + W − pairs was analysed in a data sample collected by ALEPH at a mean center-of-mass energy of 182.7 GeV, corresponding to an integrated luminosity of 57 pb −1.
21 citations
TL;DR: In this paper, a search for effectively invisible decays of the W boson in W pair production is performed, leading to an upper limit on the branching ratio of 1.3% at 95% C.L.
15 citations
TL;DR: In this article, a search for a Higgs boson decaying into invisible particles is performed using the data collected at LEP by the L3 experiment at centre-of-mass energies of 183 GeV and 189 GeV.
01 Jan 1999
TL;DR: In this paper, the mass of the W boson is obtained from reconstructed invariant mass distributions in W-pair events, and the sample of W pairs is selected from 57 pb−1 collected with the ALEPH detector in 1997 at a centre-of-mass energy of 183 GeV.
TL;DR: In this article, a study of the properties of final state particles was carried out to determine the CKM matrix element |Vcs| = 1.00±0.11stat± 0.03syst.
TL;DR: In this article, a lower bound on the mass of the Higgs boson has been established at a 95% confidence level, in agreement with the expectation of 7.2 events from background processes.
TL;DR: In this article, the authors derived limits on the production cross-section of the Higgs boson mass as a function of the mass of a Higgs particle in the reaction e+e- --> hZ, where the Z can decay into e+, e-, mu+mu- or qqbar.
TL;DR: In this paper, the average centre-of-mass energy was measured to be: E CM =182.50±0.19 ( stat. )± 0.08 ( syst. ) GeV in good agreement with the precise determination by the LEP energy working group.
TL;DR: In this article, a search for pair-produced charged Higgs bosons with masses below 59 GeV/c 2 is performed at 95% CL independently of B(H + → τ + ν τ ) under the assumption that the decay modes considered cover the totality of the possible final states.
TL;DR: In this paper, an endogenous transition from a self-sufficient traditional economy to a market economy and its consequences on fertility and growth is considered, and the transition can occur if private intergenerational transfers are unable to secure old-age consumption as adequately as savings on capital markets; otherwise individuals stay in the traditional economy unless the mass-production technology in the market economy is sufficiently more advanced than individually accessible technologies.
Abstract: This paper considers an endogenous transition from a self-sufficient traditional economy to a market economy and its consequences on fertility and growth. The transition can occur if private intergenerational transfers are unable to secure old-age consumption as adequately as savings on capital markets; otherwise individuals stay in the traditional economy unless the mass-production technology in the market economy is sufficiently more advanced than individually accessible technologies. Markets emerge only if per capita output exceeds a certain level given a fixed cost of forming markets. The transition reduces fertility and promotes growth under plausible restrictions.
JEL Classification: E20; J13; O10
TL;DR: ADA, IFN-gamma and CEA are useful parameters in differential diagnosis of tuberculous and neoplastic pleural effusion and are achieved a specificity of 95.
Abstract: BACKGROUND To study the roles of adenosine deaminase (ADA) , interferon gamma ( IFN-gamma) and carcinoembryonic antigen(CEA) for diagnosis of tuberculous and neoplastic pleural effusion. METHODS ADA , IFN-gamma and CEA activity in the serum and pleural fluid were detected in 67 patients with pleural effusion by the method of Guisti , a solid-phase enzyme-immunoassay employing the multiple antibody sandwich principle , and radioimmunoassay respectively. RESULTS The mean ADA and IFN-gamma concentration in the tuberculous pleural effusion differed significantly from those in the neoplastic pleural effusion ( P < 0. 001) . The mean CEA concentration in the serum and pleural fluid with the neoplastic pleural effusion differed from those with the tuberculous pleural effusion ( P < 0. 05) . The sensitivity of ADA (with a diagnostic threshold of 40 U/L) and IFN-gamma(threshold of 140 pg/ mL) for tuberculosis was 88 % and 96 % respectively , the specificity was 85. 71 % and 97. 62 % , and diagnostic index was 73. 71 % and 93. 62 %. Using the ADA (with below 40 U/L) and IFN-gamma (below 140 pg/mL) and CEA (above 15mug/L) , we achieved a specificity of 95. 95 %for diagnosis of neoplastic pleural effusion. CONCLUSIONS ADA , IFN-gamma and CEA are useful parameters in differential diagnosis of tuberculous and neoplastic pleural effusion.
Journal Article•
TL;DR: In this article, S. sanguis was used to prevent or reduce the colonization of the virulent P. gingivalis strain in Wistar rats for 14 days.
Abstract: OBJECTIVE To examine whether endogenous S. sanguis could prevent, or reduce the colonization of the virulent P. gingivalis strain. METHODS First, 10 specific pathogen-free Wistar rats were divided into 2 groups. Doxycycline was administered in the drinking water for 7 days. Successful implantation of the endogenous strain of S. sanguis, isolated from one of the rats before doxycycline administration, and P. gingivalis 381 within 14 days of observation were demonstrated in the rats of each group respectively. Then, 30 SPF rats were divided into 6 groups. Doxycycline was administered in the drinking water for 7 days to all the rats. Afterwards, the rats in group A and B were inoculated orally once a day for 5 days with P. gingivalis, the rats in group C and E were inoculated orally once a day for 5 days with S. sanguis. Then, the rats in group A were inoculated for 5 days with S. sanguis, and rats in group C and D were inoculated for 5 days with P. gingivalis. The rats in group F served as negative control. After inoculation, the levels of S. sanguis and P. gingivalis in the mouths of the rats were determined after 12, 24, 36 hours, 7 days and 14 days. RESULTS Both pre-colonization of S. sanguis and superinfection with S. sanguis did reduce the level of P. gingivalis in experimental rats. However, the reduction only maintained quite short time, about 36 hours. It was not caused by the decreased level of S. sanguis after 36 hours because the level of S. sanguis kept stable during the observation period of 14 days. CONCLUSION That S. sanguis function as the effector strain requires the successful implantation of S. sanguis as well as S. sanguis producing antagonistic action efficiently in vivo.
TL;DR: In this article, the 3D-quantitative structure-activity relationship on a set of 1,2,4-triazole compounds is studied, and 16 derivatives of triazole that have different biological activities to wheat black rust as inhibitors are characterized by molecular mechanics.
TL;DR: In this paper, evidence was presented for a significant, positive correlation between the total transverse momenta of particles on opposite hemispheres of hadronic events, and a new, model independent analysis of the data has been made.