Jie Zhang

Bio: Jie Zhang is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Medicine & Large Hadron Collider. The author has an hindex of 178, co-authored 4857 publications receiving 221720 citations. Previous affiliations of Jie Zhang include University of Bedfordshire & CERN.

Measurements of the production cross section of a Z boson in association with jets in pp collisions at s√=13 TeV with the ATLAS detector

Abstract: Measurements of the production cross section of a Z boson in association with jets in proton-proton collisions at root s = 13TeV are presented, using data corresponding to an integrated luminosity

Search for a light charged Higgs boson decaying to c(s)over-bar in pp collisions at root s=8 TeV

Abstract: A search for a light charged Higgs boson, originating from the decay of a top quark and subsequently decaying into a charm quark and a strange antiquark, is presented. The data used in the analysis correspond to an integrated luminosity of 19.7 inverse femtobarns recorded in proton-proton collisions at sqrt(s) = 8 TeV by the CMS experiment at the LHC. The search is performed in the process t t-bar to W+/- b H-/+ b-bar, where the W boson decays to a lepton (electron or muon) and a neutrino. The decays lead to a final state comprising an isolated lepton, at least four jets and large missing transverse energy. No significant deviation is observed in the data with respect to the standard model predictions, and model-independent upper limits are set on the branching fraction B(t to H+ b), ranging from 1.2 to 6.5% for a charged Higgs boson with mass between 90 and 160 GeV, under the assumption that B(H+ to c s-bar) = 100%.

Pileup mitigation at CMS in 13 TeV data

Abstract: With increasing instantaneous luminosity at the LHC come additional reconstruction challenges. At high luminosity, many collisions occur simultaneously within one proton-proton bunch crossing. The isolation of an interesting collision from the additional "pileup" collisions is needed for effective physics performance. In the CMS Collaboration, several techniques capable of mitigating the impact of these pileup collisions have been developed. Such methods include charged-hadron subtraction, pileup jet identification, isospin-based neutral particle "δβ" correction, and, most recently, pileup per particle identification. This paper surveys the performance of these techniques for jet and missing transverse momentum reconstruction, as well as muon isolation. The analysis makes use of data corresponding to 35.9 fb−1 collected with the CMS experiment in 2016 at a center-of-mass energy of 13 TeV. The performance of each algorithm is discussed for up to 70 simultaneous collisions per bunch crossing. Significant improvements are found in the identification of pileup jets, the jet energy, mass, and angular resolution, missing transverse momentum resolution, and muon isolation when using pileup per particle identification.

Performance Analysis of LAA and WiFi Coexistence in Unlicensed Spectrum Based on Markov Chain

Abstract: License-assisted access (LAA) is a candidate feature in 3GPP Rel-13 to meet the explosive growth of traffic demand. The main idea of LAA is to deploy LTE in the unlicensed band (mainly the 5GHz band), which is abundant with available spectrum. However, the major concern is the coexistence between WiFi and LAA in the same band. This paper presents a new framework to evaluate the downlink performance of coexisting LAA and WiFi networks. By using Markov chain, analytical models are established based on WiFi distributed coordination function (DCF) and two listen-before- talk (LBT) schemes. These two LBT schemes are Cat 3 and Cat 4 LBT, which mainly differ in medium access schemes in terms of backoff procedure. Unlike most existing works, which focus on the impact on WiFi performance posed by LAA, the performance of LAA is also evaluated. Our analysis shows that throughput of a WiFi network can be enhanced by adding or replacing WiFi access points (APs) with LAA E-UTRAN Node Bs (eNBs), at the expense of different levels of WiFi performance degradation. A trade-off between WiFi protection and LAA-WiFi system performance enhancement is observed. WiFi throughput and delay are less affected by Cat 4 LBT scheme, while Cat 3 LBT scheme provides higher LAA-WiFi system throughput. The choice of LBT schemes relies on the network planning priority, WiFi performance protection and LAA system performance requirements.

Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring

Abstract: Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers for early diagnosis and individualized treatment. Tumor markers contribute to the early diagnosis of lung cancer and play important roles in early detection and treatment, as well as in precision medicine, efficacy monitoring, and prognosis prediction. The pathological diagnosis of lung cancer in small biopsy specimens determines whether there are tumor cells in the biopsy and tumor type. Because biopsy is traumatic and the compliance of patients with multiple biopsies is poor, liquid biopsy has become a hot research direction. Liquid biopsies are advantageous because they are nontraumatic, easy to obtain, reflect the overall state of the tumor, and allow for real-time monitoring. At present, liquid biopsies mainly include circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. This review introduces the research progress and clinical application prospect of liquid biopsy technology for lung cancer.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

A new mathematical model for relative quantification in real-time RT-PCR.

Abstract: Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform, provides the necessary accuracy and produces reliable as well as rapid quantification results. But accurate quantification of nucleic acids requires a reproducible methodology and an adequate mathematical model for data analysis. This study enters into the particular topics of the relative quantification in real-time RT–PCR of a target gene transcript in comparison to a reference gene transcript. Therefore, a new mathematical model is presented. The relative expression ratio is calculated only from the real-time PCR efficiencies and the crossing point deviation of an unknown sample versus a control. This model needs no calibration curve. Control levels were included in the model to standardise each reaction run with respect to RNA integrity, sample loading and inter-PCR variations. High accuracy and reproducibility (<2.5% variation) were reached in LightCycler PCR using the established mathematical model.