Jie Zhang

Bio: Jie Zhang is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Medicine & Large Hadron Collider. The author has an hindex of 178, co-authored 4857 publications receiving 221720 citations. Previous affiliations of Jie Zhang include University of Bedfordshire & CERN.

Measurements of the nuclear modification factor for jets in Pb+Pb Collisions at √sNN = 2.76 TeV with the ATLAS detector

Abstract: Measurements of inclusive jet production are performed in pp and Pb+Pb collisions at √sNN = 2.76 TeV with the ATLAS detector at the LHC, corresponding to integrated luminosities of 4.0 pb−1 and 0.14 nb−1, respectively. The jets are identified with the anti-kt algorithm with R = 0.4, and the spectra are measured over the kinematic range of jet transverse momentum 32 < pT < 500 GeV, and absolute rapidity |y| < 2.1 and as a function of collision centrality. The nuclear modification factor, RAA, is evaluated and jets are found to be suppressed by approximately a factor of two in central collisions compared to pp collisions. The RAA shows a slight increase with pT and no significant variation with rapidity.

Measurement of jet fragmentation in PbPb and pp collisions at root s(NN)=2.76 TeV

Abstract: The jet fragmentation function of inclusive jets with transverse momentum p_T above 100GeV/c in PbPb collisions has been measured using reconstructed charged particles with p_T above 1GeV/c in a cone of radius 0.3 around the jet axis. A data sample of PbPb collisions collected in 2011 at a nucleon-nucleon center-of-mass energy of √sNN = 2.76 TeV corresponding to an integrated luminosity of 150μb^(−1) is used. The results for PbPb collisions as a function of collision centrality and jet transverse momentum are compared to reference distributions based on pp data collected at the same center-of-mass energy in 2013, with an integrated luminosity of 5.3pb^(−1). A centrality-dependent modification of the fragmentation function is found. For the most central collisions, a significant enhancement is observed in the PbPb/pp fragmentation function ratio for charged particles with p_T less than 3GeV/c. This enhancement is observed for all jet p_T bins studied.

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge.

Abstract: The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.

Study of the inclusive production of charged pions, kaons, and protons in pp collisions at √s = 0.9,2.76 and 7 TeV

Abstract: Spectra of identified charged hadrons are measured in pp collisions at the LHC for sqrt(s) = 0.9, 2.76, and 7 TeV. Charged pions, kaons, and protons in the transverse-momentum range pt approximately 0.1-1.7 GeV and for rapidities abs(y) < 1 are identified via their energy loss in the CMS silicon tracker. The average pt increases rapidly with the mass of the hadron and the event charged-particle multiplicity, independently of the center-of-mass energy. The fully corrected pt spectra and integrated yields are compared to various tunes of the PYTHIA6 and PYTHIA8 event generators.

Search for heavy Majorana neutrinos with the ATLAS detector in pp collisions at √s 8 TeV

Abstract: A search for heavy Majorana neutrinos in events containing a pair of high-p(T) leptons of the same charge and high-p(T) jets is presented. The search uses 20.3 fb(-1) of pp collision data collected with the ATLAS detector at the CERN Large Hadron Collider with a centre-of-mass energy of root s = 8TeV. The data are found to be consistent with the background-only hypothesis based on the Standard Model expectation. In the context of a Type-I seesaw mechanism, limits are set on the production cross-section times branching ratio for production of heavy Majorana neutrinos in the mass range between 100 and 500 GeV. The limits are subsequently interpreted as limits on the mixing between the heavy Majorana neutrinos and the Standard Model neutrinos. In the context of a left-right symmetric model, limits on the production cross-section times branching ratio are set with respect to the masses of heavy Majorana neutrinos and heavy gauge bosons W-R and Z'.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

A new mathematical model for relative quantification in real-time RT-PCR.

Abstract: Use of the real-time polymerase chain reaction (PCR) to amplify cDNA products reverse transcribed from mRNA is on the way to becoming a routine tool in molecular biology to study low abundance gene expression. Real-time PCR is easy to perform, provides the necessary accuracy and produces reliable as well as rapid quantification results. But accurate quantification of nucleic acids requires a reproducible methodology and an adequate mathematical model for data analysis. This study enters into the particular topics of the relative quantification in real-time RT–PCR of a target gene transcript in comparison to a reference gene transcript. Therefore, a new mathematical model is presented. The relative expression ratio is calculated only from the real-time PCR efficiencies and the crossing point deviation of an unknown sample versus a control. This model needs no calibration curve. Control levels were included in the model to standardise each reaction run with respect to RNA integrity, sample loading and inter-PCR variations. High accuracy and reproducibility (<2.5% variation) were reached in LightCycler PCR using the established mathematical model.