J
Jie Zhao
Researcher at Albert Einstein College of Medicine
Publications - 3
Citations - 966
Jie Zhao is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 3, co-authored 3 publications receiving 842 citations. Previous affiliations of Jie Zhao include Yeshiva University.
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Journal ArticleDOI
Histone H1 Depletion in Mammals Alters Global Chromatin Structure but Causes Specific Changes in Gene Regulation
Yuhong Fan,Tatiana Nikitina,Jie Zhao,Tomara J. Fleury,Riddhi Bhattacharyya,Eric E. Bouhassira,Arnold Stein,Christopher L. Woodcock,Arthur I. Skoultchi +8 more
TL;DR: Results indicate that linker histones can participate in epigenetic regulation of gene expression by contributing to the maintenance or establishment of specific DNA methylation patterns.
Journal ArticleDOI
H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.
Yuhong Fan,Tatiana Nikitina,Elizabeth M. Morin-Kensicki,Jie Zhao,Terry Magnuson,Christopher L. Woodcock,Arthur I. Skoultchi +6 more
TL;DR: It is demonstrated that the total amount of H1 is crucial for proper embryonic development and inactivating the genes for three mouse H1 subtypes showed that linker histones are essential for mammalian development.
Journal ArticleDOI
H1 histones control the epigenetic landscape by local chromatin compaction
Michael A. Willcockson,Sean E. Healton,Cary N. Weiss,Boris Bartholdy,Yair Botbol,Laxmi N. Mishra,Dhruv S. Sidhwani,Tommy J. Wilson,Hugo Pinto,Maxim I. Maron,Karin A. Skalina,Laura Norwood Toro,Laura Norwood Toro,Jie Zhao,Chul Hwan Lee,Harry Hou,Nevin Yusufova,Cem Meydan,Adewola Osunsade,Yael David,Ethel Cesarman,Ari Melnick,Simone Sidoli,Benjamin A. Garcia,Winfried Edelmann,Fernando Macian,Arthur I. Skoultchi +26 more
TL;DR: Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and histone methylation.