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Author

Jiezhun Gu

Durham University
Other affiliations: Duke University
Bio: Jiezhun Gu is an academic researcher from Durham University. The author has contributed to research in topics: Liver injury & Liver transplantation. The author has an hindex of 9, co-authored 11 publications receiving 551 citations. Previous affiliations of Jiezhun Gu include Duke University.
Topics: Liver injury, Liver transplantation, Chronic liver disease, Liver disease, Ductopenia
Papers
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Journal Article•DOI•
Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury

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Timothy Davern1, Naga Chalasani2, Robert J. Fontana3, Paul H. Hayashi4, Petr Protiva5, David E. Kleiner6, Ronald E. Engle6, Hanh Nguyen6, Suzanne U. Emerson6, Robert H. Purcell6, Hans L. Tillmann7, Jiezhun Gu7, Jose Serrano6, Jay H. Hoofnagle6 •
California Pacific Medical Center1, Indiana University2, University of Michigan3, University of North Carolina at Chapel Hill4, Yale University5, National Institutes of Health6, Durham University7
01 Nov 2011-Gastroenterology
TL;DR: HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.

295 citations

Journal Article•DOI•
Clinical and histologic features of azithromycin-induced liver injury

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Melissa Martinez1, Raj Vuppalanchi1, Robert J. Fontana2, Andrew Stolz3, David E. Kleiner4, Paul H. Hayashi5, Jiezhun Gu6, Jay H. Hoofnagle4, Naga Chalasani1 •
Indiana University1, University of Michigan2, University of Southern California3, National Institutes of Health4, University of North Carolina at Chapel Hill5, Durham University6
01 Feb 2015-Clinical Gastroenterology and Hepatology
TL;DR: Although most patients recover fully, severe cutaneous reactions, chronic injury, and serious complications leading to death or liver transplantation can occur andAzithromycin-induced liver injury occurs within 1 to 3 weeks after azithromyzin initiation and predominantly is hepatocellular in nature.

89 citations

Journal Article•DOI•
Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements.

[...]

Herbert L. Bonkovsky1, David E. Kleiner2, Jiezhun Gu3, Joseph A. Odin4, Mark Russo5, Victor M. Navarro, Robert J. Fontana6, Marwan Ghabril7, Huiman X. Barnhart3, Jay H. Hoofnagle2 •
Wake Forest Baptist Medical Center1, National Institutes of Health2, Durham University3, Icahn School of Medicine at Mount Sinai4, Carolinas Healthcare System5, University of Michigan6, Indiana University – Purdue University Indianapolis7
01 Apr 2017-Hepatology
TL;DR: Bile duct loss during acute cholestatic hepatitis is an ominous early indicator of possible vanishing bile duct syndrome (VBDS), for which at present there are no known means of prevention or therapy.

86 citations

Journal Article•DOI•
Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

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Naga Chalasani1, K. Rajender Reddy2, Robert J. Fontana3, Huiman X. Barnhart4, Jiezhun Gu4, Paul H. Hayashi5, Jawad Ahmad6, Andrew Stolz7, Víctor M. Navarro8, Jay H. Hoofnagle9 •
Indiana University1, University of Pennsylvania2, University of Michigan3, Duke University4, University of North Carolina at Chapel Hill5, Icahn School of Medicine at Mount Sinai6, University of Southern California7, Albert Einstein Medical Center8, National Institutes of Health9
01 Sep 2017-The American Journal of Gastroenterology
TL;DR: Idiosyncratic Drug Induced Liver Injury in African-Americans is associated with greater Morbidity and Mortality Compared to Caucasians as discussed by the authors, in a study conducted in the US.

49 citations

Idiosyncratic drug induced liver injury in African-Americans is associated with greater morbidity and mortality compared to Caucasians

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Naga Chalasani1, K. Rajender Reddy2, Robert J. Fontana3, Huiman X. Barnhart4, Jiezhun Gu4, Paul H. Hayashi5, Jawad Ahmad6, Andrew Stolz7, Víctor M. Navarro8, Jay H. Hoofnagle9 •
Indiana University1, University of Pennsylvania2, University of Michigan3, Duke University4, University of North Carolina at Chapel Hill5, Icahn School of Medicine at Mount Sinai6, University of Southern California7, Albert Einstein Medical Center8, National Institutes of Health9
01 Sep 2017
TL;DR: African–Americans are more likely to have severe cutaneous reactions and more severe liver injury leading to worse outcomes, including death and liver transplant, than Caucasians.
Abstract: Idiosyncratic Drug Induced Liver Injury in African–Americans Is Associated With Greater Morbidity and Mortality Compared to Caucasians

37 citations

Cited by
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Journal Article•DOI•
Hepatitis B virus infection

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Christian Trepo1, Henry Lik-Yuen Chan2, Anna Lok3•
French Institute of Health and Medical Research1, The Chinese University of Hong Kong2, University of Michigan3
06 Dec 2014-The Lancet
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.

1,137 citations

Journal Article•DOI•
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

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Naga Chalasani1, Paul H. Hayashi2, Herbert L. Bonkovsky3, Victor J. Navarro, William M. Lee4, Robert J. Fontana5 •
Indiana University1, University of North Carolina at Chapel Hill2, Carolinas Healthcare System3, University of Texas Southwestern Medical Center4, University of Michigan5
01 Jul 2014-The American Journal of Gastroenterology
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.

630 citations

Journal Article•DOI•
Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study

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Naga Chalasani1, Herbert L. Bonkovsky, Robert J. Fontana2, William M. Lee3, Andrew Stolz4, Jayant A. Talwalkar5, K. Rajendar Reddy6, Paul B. Watkins7, Victor J. Navarro8, Huiman X. Barnhart9, Jiezhun Gu9, Jose Serrano10, Jawad Ahmad, Nancy Bach, Meena B. Bansal, Huiman X. Barnhart9, Kimberly L. Beavers, Herbert L. Bonkovsky, Francisco O. Calvo, Charissa Y. Chang, Hari S. Conjeevaram, Gregory E. Conner, Jama M. Darling, Ynto S. de Boer, Douglas T. Dieterich, Frank DiPaola, Francisco A. Durazo, James E. Everhart, Robert J. Fontana2, Marwan Ghabril, David Goldstein, Vani Gopalreddy, Priya Grewal, Paul H. Hayashi, Jay H. Hoofnagle, Neil Kaplowitz, Suthat Liangpunsakul, Steven N. Lichtman, Lawrence Liu, Victor Navarro8, Joseph A. Odin, Simona Rossi, Mark W. Russo, Thomas D. Schiano, Averell H. Sherker, Raj Vuppalanchi, Paul B. Watkins7, Steven Zacks, Amanda Balasco, Kristin Chesney, Audrey Corne, Sherrie Cummings, Gale Groseclose, Alex Hammett, Judy Hooker, Varun Kesar, Sophana Mao, Kenari Marks, Regina McFadden, Yolanda Melgoza, Sherif Mikhail, Susan Milstein, Wendy Morlan, Val Peacock, Nidia Rosado, Tracy Russell, Maricruz Vega, Manisha Verma, Patricia F. Walker, Rachana Yalamanchili, Michelle McClanahan-Crowder, Katherine Galan, Tuan Chau, Kowsalya Ragavan, Hoss Rostami, Carmel Puglisi-Scharenbroich, Rebecca Torrance, Rebekah Van Raaphorst •
Indiana University1, University of Michigan2, University of Texas at Austin3, University of Southern California4, Mayo Clinic5, University of Pennsylvania6, University of North Carolina at Chapel Hill7, Albert Einstein Medical Center8, Duke University9, National Institutes of Health10
01 Jun 2015-Gastroenterology
TL;DR: In this article, the authors present characteristics and subgroup analyses from the first 1257 patients enrolled in the study, and conclude that there are no differences in outcomes of patients with short vs long latency of DILI.

576 citations

Journal Article•DOI•
EASL Clinical Practice Guidelines: Drug-induced liver injury

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Raúl J. Andrade, Guruprasad P. Aithal, Einar Björnsson, Neil Kaplowitz, Gerd A. Kullak-Ublick, Dominique Larrey, Tom H. Karlsen 
01 Jun 2019-Journal of Hepatology
TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.

504 citations

Journal Article•DOI•
Hepatitis E Virus Infection

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Nassim Kamar1, Nassim Kamar2, Harry R. Dalton3, Florence Abravanel2, Florence Abravanel1, Jacques Izopet1, Jacques Izopet2 •
Paul Sabatier University1, French Institute of Health and Medical Research2, Royal Cornwall Hospital3
01 Jan 2014-Clinical Microbiology Reviews
TL;DR: In this comprehensive review, the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries are summarized.
Abstract: Hepatitis E virus (HEV) infection is a worldwide disease. An improved understanding of the natural history of HEV infection has been achieved within the last decade. Several reservoirs and transmission modes have been identified. Hepatitis E is an underdiagnosed disease, in part due to the use of serological assays with low sensitivity. However, diagnostic tools, including nucleic acid-based tests, have been improved. The epidemiology and clinical features of hepatitis E differ between developing and developed countries. HEV infection is usually an acute self-limiting disease, but in developed countries it causes chronic infection with rapidly progressive cirrhosis in organ transplant recipients, patients with hematological malignancy requiring chemotherapy, and individuals with HIV. HEV also causes extrahepatic manifestations, including a number of neurological syndromes and renal injury. Acute infection usually requires no treatment, but chronic infection should be treated by reducing immunosuppression in transplant patients and/or the use of antiviral therapy. In this comprehensive review, we summarize the current knowledge about the virus itself, as well as the epidemiology, diagnostics, natural history, and management of HEV infection in developing and developed countries.

499 citations