Author
Jifeng Liu
Bio: Jifeng Liu is an academic researcher. The author has contributed to research in topics: Quinazolinone & One-pot synthesis. The author has an hindex of 11, co-authored 24 publications receiving 650 citations.
Papers
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TL;DR: In this article, a microwave-promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines was proposed for 2,3-disubstituted 3 H -quinazolin-4-ones.
130 citations
TL;DR: One-pot synthesis of benzimidazoles from diamines and carboxylic acids was developed under microwave irradiation condition, which provided a practical and efficient method for high-throughput synthesis of this important class of heterocyclic compounds.
89 citations
TL;DR: The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
89 citations
TL;DR: A microwave-promoted three-component one-pot reaction has been developed to provide access to the core pyrazino[2,1-b]quinazoline-3,6-dione scaffold, and highly efficient and concise total syntheses of glyantrypine, fumiquinazoline F, and fiscalin B are accomplished.
Abstract: A microwave-promoted three-component one-pot reaction has been developed to provide access to the core pyrazino[2,1-b]quinazoline-3,6-dione (1) scaffold, which is common to several families of alkaloids with significant biological activities. By adapting this synthetic strategy through the use of selected Boc-amino acids and amino acid esters, we have accomplished highly efficient and concise total syntheses of glyantrypine (2), fumiquinazoline F (3), and fiscalin B (5), achieving overall yields of 55, 39, and 20%, respectively.
79 citations
TL;DR: One-pot total syntheses of the quinazolinobenzodiazepine alkaloids sclerotigenin, +/-)-circumdatin F, and (+/-)-asperlicin C via novel microwave-assisted domino reactions were achieved in 55%, 32%, and 20% yields, respectively, from commercially available starting materials.
Abstract: One-pot total syntheses of the quinazolinobenzodiazepine alkaloids sclerotigenin (1), (±)-circumdatin F (2), and (±)-asperlicin C (3) via novel microwave-assisted domino reactions were achieved in 55%, 32%, and 20% yields, respectively, from commercially available starting materials. A two-step total synthesis of (±)-benzomalvin A (4) was accomplished with an overall yield of 16%. Additionally, analogues of circumdatin E were synthesized via the three-component one-pot sequential reactions promoted by microwave irradiation. Finally, a two-step formal total synthesis of (±)-asperlicin E (5) was also realized by using this microwave-assisted protocol.
57 citations
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TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
Abstract: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis.1 Since then, significant progress has been achieved in this discipline; many powerful single bond forming reactions and asymmetric variants have been developed. These discoveries have paved the way for the stereoselective assembly of complex organic molecules, a task deemed inconceivable by early practitioners. A great many strategies were invented by chemists in order to facilitate the synthesis of complex natural products.2 One avenue in emulating nature’s efficiency would * To whom correspondence should be addressed. E-mail: dennis.hall@ ualberta.ca. † Novartis Institute for Biomedical Research. ‡ Department of Chemistry, University of Alberta. Chem. Rev. 2009, 109, 4439–4486 4439
1,374 citations
663 citations
TL;DR: A concise account of the isolation, bioactivity, and synthesis of bioactive quinazolinone-based natural products for the period 1983-2005 is given in this paper.
607 citations
TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
531 citations
TL;DR: There are good reasons why many pharmaceutical companies are incorporating microwave chemistry into their drug discovery efforts and the many advantages of using rapid 'microwave flash heating' for chemical synthesis is the dramatic reduction in reaction times.
Abstract: In the past few years, using microwave energy to heat and drive chemical reactions has become increasingly popular in the medicinal chemistry community. First described 20 years ago, this non-classical heating method has matured from a laboratory curiosity to an established technique that is heavily used in academia and industry. One of the many advantages of using rapid 'microwave flash heating' for chemical synthesis is the dramatic reduction in reaction times--from days and hours to minutes and seconds. As will be discussed here, there are good reasons why many pharmaceutical companies are incorporating microwave chemistry into their drug discovery efforts.
531 citations