Jih-Yang Ko

TL;DR: Interference with the osteogenesis-inhibitory action of DKK1 has therapeutic potential for preventing glucocorticoid induction of osteopenia and appeared to protect bone tissue by modulating beta-catenin and Akt-mediated survival as well as the osteogenic and adipogenic activities of glucose-stressed osteoprogenitor cells.

TL;DR: Hyperglycemia impairs miR-29a signaling to intensify HDAC4 actions that contribute to podocyte protein deacetylation and degradation as well as renal dysfunction, which highlights the importance of post-translational acetylation reactions in podocyte microenvironments.

TL;DR: Extracorporeal shockwave therapy appeared to be more effective and safer than traditional conservative treatments in the management of patients with chronic patellar tendinopathy.

TL;DR: Interference with the cartilage- and bone-deleterious actions of Dkk-1 provides therapeutic potential for alleviating cartilage destruction and subchondral bone damage in OA knee joints.

TL;DR: Promotion of miR-29a signaling is an alternative strategy for alleviating glucocorticoid-induced bone deterioration and improved osteoblast differentiation and mineral acquisition.