J
Jihye Ko
Researcher at University of Massachusetts Medical School
Publications - 4
Citations - 29
Jihye Ko is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Adeno-associated virus & Expression cassette. The author has an hindex of 1, co-authored 4 publications receiving 7 citations.
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Journal ArticleDOI
Effective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold
Jun Xie,Phillip W. L. Tai,Alexander Brown,Shoufang Gong,Sha Zhu,Yi Wang,Chengjian Li,Cansu Colpan,Qin Su,Ran He,Hong Ma,Jia Li,Hanqing Ye,Jihye Ko,Phillip D. Zamore,Guangping Gao +15 more
TL;DR: It is reported that embedding the guide strand of a small silencing RNA into an artificial microRNA (miRNA) scaffold derived from mouse miRNA-33 ensures rAAV genomic integrity and reduces off-targeting by 10-fold, while maintaining effective in vivo target gene repression in mice.
Journal ArticleDOI
Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics
Wenqi Su,Wenqi Su,Shuo Sun,Shuo Sun,Bo Tian,Phillip W. L. Tai,Yongwen Luo,Jihye Ko,Wei Zhan,Xiao Ke,Qiang Zheng,Xiaorong Li,Hua Yan,Guangping Gao,Haijiang Lin +14 more
TL;DR: In this article, the authors used recombinant adeno-associated virus (rAAV)2 and rAAV8 vectors to mediate khn902 expression via a single intrastromal injection and investigated its anti-angiogenic effects and safety in both alkali-burn and suture-induced CoNV mouse models.
Journal ArticleDOI
Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette.
Sandeep R. P. Kumar,Jun Xie,Shilang Hu,Jihye Ko,Qifeng Huang,Harrison C. Brown,Alok Srivastava,David M. Markusic,Christopher B. Doering,H. Trent Spencer,Arun Srivastava,Guangping Gao,Roland W. Herzog +12 more
TL;DR: A vector genome with serotype-matched inverted terminal repeats expressing hyperactive human coagulation factor IX (FIX)-Padua was designed for clinical use that is optimized for translation using hepatocyte-specific codon-usage bias and is depleted of immune stimulatory CpG motifs.
Journal ArticleDOI
Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis
Shun-Yun Cheng,Yongwen Luo,Anneliese Malachi,Jihye Ko,Qin Su,Jun Xie,Bo Tian,Haijiang Lin,Xiao Ke,Qiang Zheng,Phillip W. L. Tai,Guangping Gao,Claudio Punzo +12 more
TL;DR: In this article, the authors show that two out of four rAAV serotypes tested by intravitreal delivery to express the anti-VEGF drug conbercept lead to a dose-dependent vascular sheathing pathology that is characterized by immune cell infiltrates, reminiscent of vasculitis.