Showing papers by "Jin Hyung Lee published in 2021"
TL;DR: qDESS prospectively enhanced with deep learning had strong inter-reader agreement with conventional knee MRI and near-equivalent diagnostic performance with respect to arthroscopy, and the ability of qDESS to automatically generate T2 maps increases sensitivity for cartilage abnormalities.
Abstract: Please see the Editorial Comment by Derik L. Davis discussing this article. BACKGROUND. Potential approaches for abbreviated knee MRI, including prospective acceleration with deep learning, have ac...
28 citations
TL;DR: In this paper, an optogenetic kindling model through repeated stimulation of ventral hippocampal CaMKII neurons in adult rats was developed to track brain-wide circuit dynamics resulting from non-afterdischarge (AD)-generating stimulations and individual convulsive seizures.
8 citations
TL;DR: In this article, the authors compared subsequent fMRI and functional ultrasound imaging (fUSI) recordings in response to direct neuronal activation via optogenetics in the same animals under an identical anesthetic protocol.
8 citations
TL;DR: In this article, optogenetic functional magnetic resonance imaging was used to map brain-wide neural circuit dynamics after stroke in mice treated with and without Optogenetic excitatory neuronal stimulations in the ipsilesional primary motor cortex (iM1).
Abstract: Poststroke optogenetic stimulations can promote functional recovery. However, the circuit mechanisms underlying recovery remain unclear. Elucidating key neural circuits involved in recovery will be invaluable for translating neuromodulation strategies after stroke. Here, we used optogenetic functional magnetic resonance imaging to map brain-wide neural circuit dynamics after stroke in mice treated with and without optogenetic excitatory neuronal stimulations in the ipsilesional primary motor cortex (iM1). We identified key sensorimotor circuits affected by stroke. iM1 stimulation treatment restored activation of the ipsilesional corticothalamic and corticocortical circuits, and the extent of activation was correlated with functional recovery. Furthermore, stimulated mice exhibited higher expression of axonal growth-associated protein 43 in the ipsilesional thalamus and showed increased Synaptophysin+/channelrhodopsin+ presynaptic axonal terminals in the corticothalamic circuit. Selective stimulation of the corticothalamic circuit was sufficient to improve functional recovery. Together, these findings suggest early involvement of corticothalamic circuit as an important mediator of poststroke recovery.
7 citations