In recent years, three-dimensional (3D) bioprinting has attracted wide research interest in biomedical engineering and clinical applications. This technology allows for unparalleled architecture control, adaptability and repeatability that can overcome the limits of conventional biofabrication techniques. Along with the emergence of a variety of 3D Bioprinting methods, bioinks have also come a long way. From their first developments to support bioprinting requirements, they are now engineered to specific injury sites requirements to mimic native tissue characteristics and to support biofunctionality. Current strategies involve the use of bioinks loaded with cells and biomolecules of interest, without altering their functions, to deliver in situ the elements required to enhance healing/regeneration. The current research and trends in bioink development for 3D Bioprinting purposes is overviewed herein.

https://iopscience.iop.org/article/10.1088/1758-5090/abec2c/pdf

Engineering bioinks for 3D bioprinting.

Microfluidic organ-on-a-chip models of human liver tissue.

Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust "alive" artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic-based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T-junction, flow-focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet-based and vesicle-based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic-based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

A critical review on quantum dots: From synthesis toward applications in electrochemical biosensors for determination of disease-related biomolecules.

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimulation. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. OOAC has broad applications in precision medicine and biological defense strategies. Here, we introduce the concepts of OOAC and review its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application.

/pdf/organ-on-a-chip-recent-breakthroughs-and-future-prospects-2f94km5r5h.pdf

Organ-on-a-chip: recent breakthroughs and future prospects

Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered as a serious threat to the human health globally. The incidence of OS is common in the metaphysis of long tubular bones, but rare in the spine, pelvis, and sacrum areas; moreover, majority of the OS patients present with only a single lesion. OS has a bimodal distribution pattern, that is, its incidence peaks in the second decade of life and in late adulthood. We examine historical and current literature to present a succinct review of OS. In this review, we have discussed the types, clinical diagnosis, and modern and future treatment methods of OS. The purpose of this article is to inspire new ideas to develop more effective therapeutic options.

/pdf/osteosarcoma-a-review-of-current-and-future-therapeutic-1vqnsc0tqj.pdf

Osteosarcoma: a review of current and future therapeutic approaches.

Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extremely small volumes of fluids is accompanied by additional benefits, most notably, rapid and efficient mass and heat transfer. In addition, reactions performed within microfluidic systems are highly controlled, meaning that many advanced materials, with uniform and bespoke properties, can be synthesized in a direct and rapid manner. In this review, we discuss the utility of microfluidic systems in the synthesis of materials for a variety of biological applications. Such materials include microparticles or microcapsules for drug delivery, nanoscale materials for medicine or cellular assays, and micro- or nanofibers for tissue engineering.

/pdf/synthesis-of-biomaterials-utilizing-microfluidic-technology-2n2ap5aqy5.pdf

Synthesis of Biomaterials Utilizing Microfluidic Technology.

In this work, we synthesized monodispersed CdSe quantum dots (QDs) by a microfluidic method and via a bulk reaction The structures of the CdSe QDs were characterized by X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM) The optical properties of the prepared CdSe QDs were determined using ultraviolet-visible absorption spectroscopy and photoluminescence spectroscopy The CdSe QDs obtained by the microfluidic method have a faster crystal growth rate and a higher absolute photoluminescence quantum yield than those obtained via the bulk reaction Additionally, we investigated the growth process of the CdSe QDs with increasing residence times

https://www.mdpi.com/2073-4352/9/7/368/pdf

Synthesis and Study of CdSe QDs by a Microfluidic Method and via a Bulk Reaction

https://www.preprints.org/manuscript/201805.0004/v1/download

Jinfeng Liu

Papers

Organ-on-a-chip: recent breakthroughs and future prospects

Osteosarcoma: a review of current and future therapeutic approaches.

Synthesis of Biomaterials Utilizing Microfluidic Technology.

Synthesis and Study of CdSe QDs by a Microfluidic Method and via a Bulk Reaction

The Pollutant Particle Size and Chemistry Matters