J
Jing Gung Chung
Researcher at China Medical University (Taiwan)
Publications - 517
Citations - 18241
Jing Gung Chung is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Apoptosis & Cancer cell. The author has an hindex of 63, co-authored 515 publications receiving 16104 citations. Previous affiliations of Jing Gung Chung include China Medical University (PRC) & Asia University (Taiwan).
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Journal ArticleDOI
Quercetin-mediated Cell Cycle Arrest and Apoptosis Involving Activation of a Caspase Cascade through the Mitochondrial Pathway in Human Breast Cancer MCF-7 Cells
Chu Chung Chou,Jai Sing Yang,Hsu Feng Lu,Siu Wan Ip,Chyi Lo,Chih-Chung Wu,Jing Pin Lin,Nou Ying Tang,Jing Gung Chung,Ming Jen Chou,Ying Hock Teng,Dar-Ren Chen +11 more
TL;DR: It is suggested that quercetin may induce apoptosis by direct activation of the caspase cascade through the mitochondrial pathway in MCF-7 cells.
Journal Article
Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways
Shin Hwar Wu,Liang Wen Hang,Jai Sing Yang,Hung-Yi Chen,Hui-Yi Lin,Jo Hua Chiang,Chi Cheng Lu,Jiun Long Yang,Tung Yuan Lai,Yang Ching Ko,Jing Gung Chung +10 more
TL;DR: Curcumin exerts its anticancer effects on lung cancer NCI-H460 cells through apoptosis or cell cycle arrest and down-regulation of cyclin-dependent kinase 1 (CDK1) is involved.
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Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)
Song Shei Lin,Kuang Chi Lai,Shu Chun Hsu,Jai Sing Yang,Chao Lin Kuo,Jing Pin Lin,Yi Shih Ma,Chih-Chung Wu,Jing Gung Chung +8 more
TL;DR: Curcumin suppressed the migration and invasion of human non-small cell lung cancer cells (A549) in vitro and suggests that curcumin has anti-metastatic potential by decreasing invasiveness of cancer cells.
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Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells.
Su Yu Chien,Yao Chung Wu,Jing Gung Chung,Jai Sing Yang,Hsu Feng Lu,Mei Fen Tsou,Wg Wood,Shou Jen Kuo,Dar-Ren Chen +8 more
TL;DR: Findings suggest that quercetin results in human breast cancer MDA-MB-231 cell death through mitochondrial- and caspase-3-dependent pathways.
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Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells
Chi Cheng Lu,Jai Sing Yang,An Cheng Huang,Te Chun Hsia,Su Tze Chou,Chao Lin Kuo,Hsu Feng Lu,Tsung-Han Lee,W. G. Wood,Jing Gung Chung,Jing Gung Chung +10 more
TL;DR: Human liver cancer cells treated with chrysophanol exhibited a cellular pattern associated with necrosis and not apoptosis, and reductions in adenosine triphosphate levels and increases in lactate dehydrogenase activity indicated that chrysophile stimulated necrotic cell death.