J
Jing Wu
Researcher at National Institutes of Health
Publications - 62
Citations - 1046
Jing Wu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 42 publications receiving 705 citations. Previous affiliations of Jing Wu include University of North Carolina at Chapel Hill.
Papers
More filters
Journal ArticleDOI
Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.
Yanxin Lu,Jakub Kwintkiewicz,Yang Liu,Katherine Tech,Lauren N. Frady,Yu Ting Su,Wendy Bautista,Seog In Moon,Jeffrey M. Macdonald,Matthew G. Ewend,Mark R. Gilbert,Chunzhang Yang,Jing Wu +12 more
TL;DR: It is found that defects in oxidative metabolism and 2-HG production confer chemosensitization in IDH1-mutated glioma cells and that targeting PARP-associated DNA repair may represent a novel therapeutic strategy for gliomas.
Journal ArticleDOI
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Vijay Ramaswamy,Thomas Hielscher,Stephen C. Mack,Stephen C. Mack,Alvaro Lassaletta,Tong Lin,Kristian W. Pajtler,David T.W. Jones,Betty Luu,Florence M.G. Cavalli,Kenneth Aldape,Marc Remke,Martin Mynarek,Stefan Rutkowski,Sridharan Gururangan,Roger E. McLendon,Eric S. Lipp,Christopher Dunham,Juliette Hukin,David D. Eisenstat,Dorcas Fulton,Frank van Landeghem,Mariarita Santi,Marie Lise C. van Veelen,Erwin G. Van Meir,Satoru Osuka,Xing Fan,Karin M. Muraszko,Daniela Pretti da Cunha Tirapelli,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Carlos Gilberto Carlotti,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Claudia C. Faria,Sofia Nunes,Jaume Mora,Ronald L. Hamilton,Peter Hauser,Nada Jabado,Kevin Petrecca,Shin Jung,Luca Massimi,Massimo Zollo,Giuseppe Cinalli,László Bognár,Almos Klekner,Tibor Hortobágyi,Sarah Leary,Sarah Leary,Sarah Leary,Ralph P. Ermoian,Ralph P. Ermoian,Ralph P. Ermoian,James M. Olson,James M. Olson,James M. Olson,Jeffrey R. Leonard,Corrine Gardner,Wiesława Grajkowska,Lola B. Chambless,Jason E. Cain,Charles G. Eberhart,Sama Ahsan,Maura Massimino,Felice Giangaspero,Francesca R. Buttarelli,Roger J. Packer,Lyndsey Emery,William H. Yong,Horacio Soto,Linda M. Liau,Richard Everson,Andrew J. Grossbach,Tarek Shalaby,Michael A. Grotzer,Matthias A. Karajannis,David Zagzag,Helen Wheeler,Katja von Hoff,Marta M. Alonso,Teresa Tuñón,Ulrich Schüller,Karel Zitterbart,Jaroslav Sterba,Jennifer A. Chan,Miguel A. Guzman,Samer K. Elbabaa,Howard Colman,Girish Dhall,Paul G. Fisher,Maryam Fouladi,Amar Gajjar,Stewart Goldman,Eugene Hwang,Marcel Kool,Harshad Ladha,Elizabeth Vera-Bolanos,Khalida Wani,Frank S. Lieberman,Tom Mikkelsen,Antonio Omuro,Ian F. Pollack,Michael D. Prados,H. Ian Robins,Riccardo Soffietti,Jing Wu,Phillipe Metellus,Uri Tabori,Ute Bartels,Eric Bouffet,Cynthia Hawkins,James T. Rutka,Peter B. Dirks,Stefan M. Pfister,Stefan M. Pfister,Thomas E. Merchant,Mark R. Gilbert,Mark R. Gilbert,Terri S. Armstrong,Andrey Korshunov,David W. Ellison,Michael D. Taylor +123 more
TL;DR: The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy.
Journal ArticleDOI
Biology and management of ependymomas
TL;DR: An in-depth understanding of tumor biology, developing reliable animal models that accurately reflect tumor molecule features, and high throughput drug screening are essential for developing new therapies.
Journal ArticleDOI
MGMT Status as a Clinical Biomarker in Glioblastoma.
Madison Butler,Lorinc Pongor,Yu-Ting Su,Liqiang Xi,Mark Raffeld,Martha Quezado,Jane B. Trepel,Kenneth Aldape,Yves Pommier,Jing Wu +9 more
TL;DR: The discordance between MGMT methylation, expression, and patient outcome, which currently challenges the implementation of this biomarker in clinical practice is elucidated.
Journal ArticleDOI
Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients
Elizabeth Vera-Bolanos,Kenneth Aldape,Ying Yuan,Jimin Wu,Khalida Wani,Mary Jo T. Necesito-Reyes,Howard Colman,Girish Dhall,Frank S. Lieberman,Philippe Metellus,Tom Mikkelsen,Antonio Omuro,Sonia Partap,Michael D. Prados,H. Ian Robins,Riccardo Soffietti,Jing Wu,Mark R. Gilbert,Terri S. Armstrong +18 more
TL;DR: Findings from an ongoing, multicenter collaboration from a collection of clinically annotated adult ependymoma tumor samples demonstrating distinct predictors of progression-free survival are reported.