J
Jingbo Pi
Researcher at China Medical University (PRC)
Publications - 161
Citations - 9976
Jingbo Pi is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 50, co-authored 140 publications receiving 8357 citations. Previous affiliations of Jingbo Pi include University of California, Irvine & COMSATS Institute of Information Technology.
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Journal ArticleDOI
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy,Nicola J. Hewitt,Ute Albrecht,Melvin E. Andersen,Nariman Ansari,Sudin Bhattacharya,Johannes G. Bode,Jennifer Bolleyn,Christoph Borner,J Böttger,Albert Braeuning,Robert A. Budinsky,Britta Burkhardt,Neil R. Cameron,Giovanni Camussi,Chong Su Cho,Yun Jaie Choi,J. Craig Rowlands,Uta Dahmen,Georg Damm,Olaf Dirsch,María Teresa Donato,Jian Dong,Steven Dooley,Dirk Drasdo,Dirk Drasdo,Dirk Drasdo,Rowena Eakins,Karine Sá Ferreira,Valentina Fonsato,Joanna Fraczek,Rolf Gebhardt,Andrew Gibson,Matthias Glanemann,Christopher E. Goldring,María José Gómez-Lechón,Geny M. M. Groothuis,Lena Gustavsson,Christelle Guyot,David Hallifax,Seddik Hammad,Adam S. Hayward,Dieter Häussinger,Claus Hellerbrand,Philip Hewitt,Stefan Hoehme,Hermann-Georg Holzhütter,J. Brian Houston,Jens Hrach,Kiyomi Ito,Hartmut Jaeschke,Verena Keitel,Jens M. Kelm,B. Kevin Park,Claus Kordes,Gerd A. Kullak-Ublick,Edward L. LeCluyse,Peng Lu,Jennifer Luebke-Wheeler,Anna Lutz,Daniel J. Maltman,Madlen Matz-Soja,Patrick D. McMullen,Irmgard Merfort,Simon Messner,Christoph Meyer,Jessica Mwinyi,Dean J. Naisbitt,Andreas K. Nussler,Peter Olinga,Francesco Pampaloni,Jingbo Pi,Linda J. Pluta,Stefan Przyborski,Anup Ramachandran,Vera Rogiers,Cliff Rowe,Celine Schelcher,Kathrin Schmich,Michael Schwarz,Bijay Singh,Ernst H. K. Stelzer,Bruno Stieger,Regina Stöber,Yuichi Sugiyama,Ciro Tetta,Wolfgang E. Thasler,Tamara Vanhaecke,Mathieu Vinken,Thomas S. Weiss,Agata Widera,Courtney G. Woods,Jinghai James Xu,Kathy Yarborough,Jan G. Hengstler +94 more
TL;DR: This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
Journal ArticleDOI
Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion
Jingbo Pi,Yushi Bai,Qiang Zhang,Victoria A. Wong,Lisa M. Floering,Kiefer W. Daniel,Jeffrey M. Reece,Jude T. Deeney,Melvin E. Andersen,Barbara E. Corkey,Sheila Collins +10 more
TL;DR: Findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function.
Journal ArticleDOI
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
Brian N. Chorley,Michelle R. Campbell,Xuting Wang,Mehmet Karaca,Deepa Sambandan,Fatu Bangura,Peng Xue,Jingbo Pi,Steven R. Kleeberger,Douglas A. Bell +9 more
TL;DR: Validation of selected candidate genes using parallel ChIP techniques and in NRF2-silenced cell lines indicated that the expression of about two-thirds of the candidates are likely to be directly NRF1-dependent including retinoid X receptor alpha (RXRA), which has implications for response to retinoids treatments and adipogenesis.
Journal ArticleDOI
Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review
Elizabeth A. Maull,Habibul Ahsan,Joshua R. Edwards,Matthew P. Longnecker,Ana Navas-Acien,Jingbo Pi,Ellen K. Silbergeld,Miroslav Styblo,Chin-Hsiao Tseng,Kristina A. Thayer,Dana Loomis +10 more
TL;DR: The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure in populations with relatively high exposure levels, although recent studies with better measures of outcome and exposure support an association.
Journal ArticleDOI
Epigallocatechin-3-gallate (egcg), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-amp-activated protein kinase
TL;DR: An inhibitory role for EGCG is demonstrated in isolated hepatocytes in hepatic gluconeogenesis and new light is shed on the mechanism by which E GCG suppresses gluc oneogenesis.