J
Jingjin Ding
Researcher at Chinese Academy of Sciences
Publications - 35
Citations - 6868
Jingjin Ding is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Pyroptosis & Medicine. The author has an hindex of 17, co-authored 29 publications receiving 3662 citations.
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Journal ArticleDOI
Pore-forming activity and structural autoinhibition of the gasdermin family
Jingjin Ding,Kun Wang,Wang Liu,Yang She,Qi Sun,Jianjin Shi,Hanzi Sun,Da-Cheng Wang,Da-Cheng Wang,Feng Shao +9 more
TL;DR: It is demonstrated that the liposome-leakage and pore-forming activities of the gasdermin-N domain are required for pyroptosis and provide insights into the roles of theGasdermin family in necrosis, immunity and diseases.
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Inflammatory caspases are innate immune receptors for intracellular LPS
TL;DR: It is shown that human monocytes, epithelial cells and keratinocytes undergo necrosis upon cytoplasmic delivery of LPS, which represents a new mode of pattern recognition in immunity and also an unprecedented means of caspase activation.
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
TL;DR: It is shown that GSDME, which was originally identified as DFNA5 (deafness, autosomal dominant 5), can switch caspase-3-mediated apoptosis induced by TNF or chemotherapy drugs to pyroptosis, suggesting that casp enzyme activation can trigger necrosis by cleaving G SDME and offer new insights into cancer chemotherapy.
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Zhiwei Zhou,Huabin He,Kun Wang,Xuyan Shi,Yupeng Wang,Ya Su,Yao Wang,Da Li,Wang Liu,Yongliang Zhang,Lianjun Shen,Weidong Han,Lin Shen,Jingjin Ding,Feng Shao +14 more
TL;DR: It is shown that granzyme A cleaves and activates gasdermin B (GSDMB), a central player in the highly inflammatory cell death process known as pyroptosis, suggesting that this pathway may be a target for future cancer immunotherapies.
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A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis
Qinyang Wang,Yupeng Wang,Jingjin Ding,Chunhong Wang,Xuehan Zhou,Wenqing Gao,Huanwei Huang,Feng Shao,Feng Shao,Zhibo Liu +9 more
TL;DR: In mouse models of cancer, a biorthogonal chemical system based on desilylation catalysed by phenylalanine trifluoroborate enables the controlled release of gasdermin to induce pyroptosis selectively in tumour cells, suggesting that pyroPTosis-induced inflammation triggers robust antitumour immunity and can synergize with checkpoint blockade.