Author
Jingtao Zhang
Bio: Jingtao Zhang is an academic researcher from University of Nantes. The author has contributed to research in topics: Microstructure & Materials science. The author has an hindex of 5, co-authored 5 publications receiving 662 citations.
Papers
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TL;DR: An overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties shows that, although the mechanical strength of CPC's is generally low, it is not a critical issue for their application for bone repair.
528 citations
TL;DR: Evidence from in vivo studies shows the existence of newly formed bone within the implantation site, indicating the feasibility and effectiveness of this foaming strategy, which could be used in various CPC systems using other hydrophilic viscous polymeric solutions.
69 citations
TL;DR: In this paper, the influence of microstructural parameters on apatite cements has been investigated in a systematic manner, and the knowledge gained should allow, in the end, to improve mechanical properties by controlling the microstructure, and to find a better compromise between strength and biological behaviour.
68 citations
TL;DR: It was found that Si-HPMC could endow composite CPC pastes with an appealing rheological behavior at the early stage of setting, promoting its application in open bone cavities and may be particularly promising as bone substitute material for clinic application.
68 citations
TL;DR: The molecular weight of CEAs played a major role compared to their degree of substitution in CPCs' performances, and had an evident toughening effect on CPCs, inducing a significant tolerance to damage.
67 citations
Cited by
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TL;DR: An overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties shows that, although the mechanical strength of CPC's is generally low, it is not a critical issue for their application for bone repair.
528 citations
TL;DR: The overall objective of this paper is to gather the current knowledge on osteoinductivity of bone grafting materials for the effective development of new graft substitutes that enhance bone regeneration.
445 citations
TL;DR: Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues.
Abstract: Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization-remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.
408 citations
TL;DR: This article provides a concise review of recent advances in the R & D of 3D printing of bone tissue engineering scaffolds and presents the philosophy and research in the designing and fabrication of Bone tissue Engineering scaffolds through3D printing.
343 citations
TL;DR: Structural and mechanical characterization shows "brick-and-mortar" structures, akin to nacre, with interesting combinations of strength, stiffness, and work of fracture, which provide a pathway to making strong and tough lightweight materials.
Abstract: Using a bidirectional freezing technique, combined with uniaxial pressing and in situ polymerization, "nacre-mimetic" hydroxyapatite/poly(methyl methacrylate) (PMMA) composites are developed by processing large-scale aligned lamellar ceramic scaffolds. Structural and mechanical characterization shows "brick-and-mortar" structures, akin to nacre, with interesting combinations of strength, stiffness, and work of fracture, which provide a pathway to making strong and tough lightweight materials.
299 citations