J
Jingxuan Yang
Researcher at University of Oklahoma Health Sciences Center
Publications - 58
Citations - 3388
Jingxuan Yang is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Pancreatic cancer & Metastasis. The author has an hindex of 29, co-authored 51 publications receiving 2610 citations. Previous affiliations of Jingxuan Yang include University of Texas Health Science Center at Houston & Cornell University.
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Journal ArticleDOI
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
Chioniso P. Masamha,Zheng Xia,Jingxuan Yang,Todd R. Albrecht,Min Li,Ann-Bin Shyu,Wei Li,Eric J. Wagner +7 more
TL;DR: CFIm25 is identified as a broad repressor of proximal poly(A) site usage that, when depleted, increases cell proliferation and is revealed as a previously unknown connection between CFIm25 and glioblastoma tumorigenicity.
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Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2.
Qun Chen,Qun Chen,Jinquan Cai,Jinquan Cai,Qixue Wang,Yunfei Wang,Mingyang Liu,Jingxuan Yang,Junhu Zhou,Chunsheng Kang,Min Li,Chuanlu Jiang,Chuanlu Jiang +12 more
TL;DR: The EGFR/NEAT1/EZH2/β-catenin axis serves as a critical effector of tumorigenesis and progression, suggesting new therapeutic directions in glioblastoma.
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Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets.
TL;DR: The most common and important pathways that are highly mutated or deregulated in GBM are summarized and potential therapeutic strategies targeting these pathways are discussed.
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Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner.
Kailiang Zhang,Xiaotian Sun,Xuan Zhou,Lei Han,Luyue Chen,Zhendong Shi,Anling Zhang,Minhua Ye,Qixue Wang,Chaoyong Liu,Jianwei Wei,Yu Ren,Jingxuan Yang,Jianning Zhang,Peiyu Pu,Min Li,Chunsheng Kang +16 more
TL;DR: It is found that EZH2 (predominant PRC2 complex component) inhibition blocked cell cycle progression in glioma cells, consistent with the effects elicited by HOTAIR siRNA.
Journal ArticleDOI
Overcoming drug resistance in pancreatic cancer
Jiang Long,Yuqing Zhang,Xianjun Yu,Jingxuan Yang,Drake G. LeBrun,Changyi Chen,Qizhi Yao,Min Li +7 more
TL;DR: This review summarizes recent advances in the mechanisms of drug resistance in pancreatic cancer and potential strategies to overcome this and recommends novel therapeutic strategies to increase the efficacy of current treatments in a wide variety of human cancers.