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Jinho Yang

Bio: Jinho Yang is an academic researcher from Korea University. The author has contributed to research in topics: Microbiome & Extracellular vesicle. The author has an hindex of 14, co-authored 38 publications receiving 617 citations.

Papers
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Journal ArticleDOI
TL;DR: The results of the present study suggest that the bodily microbiota profile is altered in Tg-APP/PS1 mice, and that blood EVs are useful for the metagenome analysis of bodily microbiota in AD.
Abstract: Emerging evidence has suggested that the gut microbiota contribute to brain dysfunction, including pathological symptoms of Alzheimer disease (AD). Microbiota secrete membrane vesicles, also called extracellular vesicles (EVs), which contain bacterial genomic DNA fragments and other molecules and are distributed throughout the host body, including blood. In the present study, we investigated whether bacteria-derived EVs in blood are useful for metagenome analysis in an AD mouse model. Sequence readings of variable regions of 16S rRNA genes prepared from blood EVs in Tg-APP/PS1 mice allowed us to identify over 3,200 operational taxonomic units corresponding to gut microbiota reported in previous studies. Further analysis revealed a distinctive microbiota landscape in Tg-APP/PS1 mice, with a dramatic alteration in specific microbiota at all taxonomy levels examined. Specifically, at the phylum level, the occupancy of p_Firmicutes increased, while the occupancy of p_Proteobacteria and p_Bacteroidetes moderately decreased in Tg-APP/PS1 mice. At the genus level, the occupancy of g_Aerococcus, g_Jeotgalicoccus, g_Blautia, g_Pseudomonas and unclassified members of f_Clostridiale and f_Ruminococcaceae increased, while the occupancy of g_Lactobacillus, unclassified members of f_S24-7, and g_Corynebacterium decreased in Tg-APP/PS1 mice. A number of genus members were detected in Tg-APP/PS1 mice, but not in wild-type mice, while other genus members were detected in wild-type mice, but lost in Tg-APP/PS1 mice. The results of the present study suggest that the bodily microbiota profile is altered in Tg-APP/PS1 mice, and that blood EVs are useful for the metagenome analysis of bodily microbiota in AD.

94 citations

Journal ArticleDOI
TL;DR: Findings support the critical mediating role of the gut microbiota in diet-induced CRC risk as well as the potential of dietary grain intake to reduce microbiota-associated CRC risk.
Abstract: Colorectal cancer (CRC) is the third most common form of cancer and poses a critical public health threat due to the global spread of westernized diets high in meat, cholesterol, and fat. Although the link between diet and colorectal cancer has been well established, the mediating role of the gut microbiota remains elusive. In this study, we sought to elucidate the connection between the gut microbiota, diet, and CRC through metagenomic analysis of bacteria isolated from the stool of CRC (n = 89) and healthy (n = 161) subjects. This analysis yielded a dozen genera that were significantly altered in CRC patients, including increased Bacteroides, Fusobacterium, Dorea, and Porphyromonas prevalence and diminished Pseudomonas, Prevotella, Acinetobacter, and Catenibacterium carriage. Based on these altered genera, we developed two novel CRC diagnostic models through stepwise selection and a simplified model using two increased and two decreased genera. As both models yielded strong AUC values above 0.8, the simplified model was applied to assess diet-based CRC risk in mice. Mice fed a westernized high-fat diet (HFD) showed greater CRC risk than mice fed a regular chow diet. Furthermore, we found that nonglutinous rice, glutinous rice, and sorghum consumption reduced CRC risk in HFD-fed mice. Collectively, these findings support the critical mediating role of the gut microbiota in diet-induced CRC risk as well as the potential of dietary grain intake to reduce microbiota-associated CRC risk. Further study is required to validate the diagnostic prediction models developed in this study as well as the preventive potential of grain consumption to reduce CRC risk. Tracing biomarkers of gut bacteria sheds light on how diet can affect gut composition and the risk of developing colorectal cancer (CRC). CRC is linked to diet, and scientists are examining how diet-associated changes in the gut microbiome may influence cancer risk. Yoon-Keun Kim, MD Healthcare Inc., Seoul, and Young-Koo Jee, Dankook University College of Medicine, Cheonan, South Korea, and co-workers analyzed bacterial populations in fecal samples from 89 CRC patients and 161 healthy controls. They found significant differences between patients and controls in 16 bacterial genera, these differences being potential biomarkers in diagnostic models for assessing CRC risk. The researchers used the models to determine CRC risk in mice fed diets, and found that the predicted risk was considerably reduced in mice on grain diets, especially rice or sorghum, compared to high fat diets.

93 citations

Journal ArticleDOI
Hyunjun Yun1, Insick Nam1, Jinman Kim1, Jinho Yang1, Kyoung Ho Lee2, Jongryeul Sohn1 
TL;DR: In this article, the dry-bulb temperature, relative humidity, the airflow velocity, and the globe temperature were measured at 10 randomly selected kindergartens from April to June, 2013, and a survey was conducted three times a day for 119 kindergarten children to investigate their thermal comfort, clothing insulation, and metabolism.

76 citations

Journal ArticleDOI
Hyeon-Ju Oh1, In Sick Nam1, Hyunjun Yun1, Jinman Kim1, Jinho Yang1, Jong Ryeul Sohn1 
TL;DR: In this article, the average indoor concentrations of fine particles less than 2.5μm were collected from inside ten childcare centers, and from their adjacent outdoor environments in Seoul, Korea during the summer, autumn and winter seasons.

75 citations

Journal ArticleDOI
TL;DR: In this article, a survey at 26 ECCs in Korea between April 2013 and March 2014 was conducted to characterize the influence of seasonality on elderly care centers (ECCs) thermal environments; analyze elderly physical conditions; and assess indoor environments thermal parameters in Korean ECC.

67 citations


Cited by
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Book ChapterDOI
01 Jan 2010

5,842 citations

Book ChapterDOI
01 Jan 2014
TL;DR: In this paper, a revision of the previous edition article by Robert Visser, volume 4, pp 551-560, is presented. But this article is based on the previous version of the article.
Abstract: This article is a revision of the previous edition article by Robert Visser, volume 4, pp 551–560, © 2005, Elsevier Inc.

766 citations

Journal ArticleDOI
TL;DR: In this paper, a review of the literature on human thermal comfort in the built environment is presented, which includes standards, indoor experiments in controlled environments, indoor field studies in educational, office, residential and other building types, productivity, human physiological models, outdoor and semi-outdoor field studies.

609 citations

Journal ArticleDOI
TL;DR: In this article, the authors examined the magnitude and significance of individual differences in the preferred/neutral/comfort temperature through reviewing previous climate chamber and field studies, including sex, age and etc.

352 citations

Journal ArticleDOI
TL;DR: How ultrafine particles measuring less than 100 nanometres in diameter elicit greater inflammatory responses and stay in the lungs longer than larger particles is described, which can trigger heart disease, diabetes, cancer, neurological disorders and respiratory ailments, especially among children and people with long-term occupational exposure.
Abstract: Ultrafine particles (PM0.1), which are present in the air in large numbers, pose a health risk. They generally enter the body through the lungs but translocate to essentially all organs. Compared to fine particles (PM2.5), they cause more pulmonary inflammation and are retained longer in the lung. Their toxicity is increased with smaller size, larger surface area, adsorbed surface material, and the physical characteristics of the particles. Exposure to PM0.1 induces cough and worsens asthma. Metal fume fever is a systemic disease of lung inflammation most likely caused by PM0.1. The disease is manifested by systemic symptoms hours after exposure to metal fumes, usually through welding. PM0.1 cause systemic inflammation, endothelial dysfunction, and coagulation changes that predispose individuals to ischemic cardiovascular disease and hypertension. PM0.1 are also linked to diabetes and cancer. PM0.1 can travel up the olfactory nerves to the brain and cause cerebral and autonomic dysfunction. Moreover, in utero exposure increases the risk of low birthweight. Although exposure is commonly attributed to traffic exhaust, monitored students in Ghana showed the highest exposures in a home near a trash burning site, in a bedroom with burning coils employed to abate mosquitos, in a home of an adult smoker, and in home kitchens during domestic cooking. The high point-source production and rapid redistribution make incidental exposure common, confound general population studies and are compounded by the lack of global standards and national reporting. The potential for PM0.1 to cause harm to health is great, but their precise role in many illnesses is still unknown and calls for more research.

333 citations