J
Jinpei Zhou
Researcher at China Pharmaceutical University
Publications - 42
Citations - 485
Jinpei Zhou is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Nitric oxide & Licofelone. The author has an hindex of 12, co-authored 42 publications receiving 441 citations. Previous affiliations of Jinpei Zhou include Free University of Berlin.
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Synthesis and in vitro antitumor activity of novel scopoletin derivatives
TL;DR: Primary screening against mammary and colon carcinoma cells indicated that the modification of the scopoletin structure could greatly increase its antitumor activity in vitro.
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Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Wukun Liu,Jinpei Zhou,Tong Zhang,Haiyang Zhu,Hai Qian,Huibin Zhang,Wenlong Huang,Ronald Gust,Ronald Gust +8 more
TL;DR: Thiourea derivatives (6a-e) showed stronger anti-inflammatory activity than ibuprofen in vivo in the xylene-induced ear swelling assay in mice, and exhibited growth inhibitory effects comparable to 5-fluorouracil in vitro.
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Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents.
TL;DR: The preliminary pharmacological profile of compound 10 showed that it might be useful in the treatment of diabetics with cardiovascular and nephropathy complications and showed an excellent property to protect collagen-epinephrine-induced mice mortality.
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Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
Wukun Liu,Jinpei Zhou,Kerstin Bensdorf,Huibin Zhang,Haoran Liu,Yubin Wang,Hai Qian,Yanchun Zhang,Anja Wellner,Gerhard Rubner,Wenlong Huang,Can-Cheng Guo,Ronald Gust,Ronald Gust +13 more
TL;DR: A series of C5-substituted licofelone derivatives developed by a parallel synthesis approach and investigated for cytotoxicity against MCF-7 and MDA-MB-231 cells as well as for anti-inflammatory potency in vitro and in vivo showed high selectivity for MCf-7 cells.
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2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.
TL;DR: Fourteen new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and three of them were enantiomerically pure, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum.