J
Jinsong Li
Researcher at Sun Yat-sen University
Publications - 72
Citations - 1913
Jinsong Li is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Metastasis & Medicine. The author has an hindex of 20, co-authored 63 publications receiving 1455 citations. Previous affiliations of Jinsong Li include Memorial Hospital of South Bend.
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MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor
Jinsong Li,Hong-Zhang Huang,Lijuan Sun,Mei Yang,Chaobin Pan,Wei-liang Chen,Donghui Wu,Zhaoyu Lin,Chunxian Zeng,Yandan Yao,Peter Zhang,Erwei Song +11 more
Abstract: Purpose: We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis. Experimental Design: MicroRNA profiling was done in 10 cases of TSCC with microarray. MiR-21 overexpression was quantitated with quantitative reverse transcription-PCR in 103 patients, and correlated to the pathoclinical status of the patients. Immunohistochemistry was used to examine the expression of TPM1 and PTEN , and terminal deoxynucleotidyl transferase–mediated dUTP labeling to evaluate apoptosis. Moreover, miR-21 antisense oligonucleotide (ASO) was transfected in SCC-15 and CAL27 cell lines, and tumor cell growth was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, adherent colony formation, and soft agar assay, whereas apoptosis was determined by Annexin V assay, cytochrome c release, and caspase 3 assay. Tumorigenesis was evaluated by xenografting SCC-15 cells in nude mice. Results: MiR-21 is overexpressed in TSCC relative to adjacent normal tissues. The level of miR-21 is reversely correlated with TPM1 and PTEN expression and apoptosis of cancer cells. Multivariate analysis showed that miR-21 expression is an independent prognostic factor indicating poor survival. Inhibiting miR-21 with ASO in TSCC cell lines reduces survival and anchorage-independent growth, and induces apoptosis in TSCC cell lines. Simultaneous silencing of TPM1 with siRNA only partially recapitulates the effect of miR-21 ASO. Furthermore, repeated injection of miR-21 ASO suppresses tumor formation in nude mice by reducing cell proliferation and inducing apoptosis. Conclusions: miR-21 is an independent prognostic indicator for TSCC, and may play a role in TSCC development by inhibiting cancer cell apoptosis partly via TPM1 silencing.
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Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition
TL;DR: It is shown that NKILA is down-regulated in TSCC cancer tissues than that in matched adjacent noncancerous tissues and this function could act as a potential predictor for overall survival in patients with TSCC and a potential therapeutic target for TSCC intervention.
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A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma.
Song Fan,Qiong-lan Tang,Ying-Jin Lin,Wei-liang Chen,Jinsong Li,Zhi-quan Huang,Zhao-hui Yang,You-yuan Wang,Da-ming Zhang,Hui-Jing Wang,Eduardo Dias-Ribeiro,Qiang Cai,Lei Wang +12 more
TL;DR: Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient.
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Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma.
Li Peng,Li Peng,Jiang Binyuan,Xiaoqing Yuan,Yuntan Qiu,Jiangyun Peng,Yongsheng Huang,Chaoyang Zhang,Yin Zhang,Zhaoyu Lin,Jinsong Li,Weicheng Yao,Weixi Deng,Ya-Qin Zhang,Meng Meng,Xi Pan,Chunquan Li,Dong Yin,Xinyu Bi,Guancheng Li,Guancheng Li,De-Chen Lin +21 more
TL;DR: HCCL5 was transcriptionally driven by ZEB1 via a super-enhancer and was significantly and frequently overexpressed in human HCC tissues, correlating with worse overall survival of patients with HCC, and the data suggest that HCCL 5 may serve as a novel prognostic biomarker and therapeutic target in HCC.
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Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription
Song Fan,Song Fan,Song Fan,Tian Tian,Weixiong Chen,Xiao-Bin Lv,Xiao-Bin Lv,Xinyuan Lei,Hanqing Zhang,Sheng Sun,Lei Cai,Guokai Pan,Lile He,Zhanpeng Ou,Xinyu Lin,Xinhui Wang,Matthew Francis Perez,Zhiming Tu,Soldano Ferrone,Bakhos A. Tannous,Jinsong Li,Jinsong Li +21 more
TL;DR: The mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycolysis and uncovered a novel mechanism by which mitomiRNA regulates mitochondrial transcription.