Jiong Hu

TL;DR: The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. as mentioned in this paper summarizes the physiological and pathophysiological importance of the AA metabolizing pathways and outlines the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression.

TL;DR: Control by the histone demethylase JARID1B, MANTIS was downregulated in patients with idiopathic pulmonary arterial hypertension and in rats treated with monocrotaline, whereas it was upregulated in carotid arteries of Macaca fascicularis subjected to atherosclerosis regression diet, and in endothelial cells isolated from human glioblastoma patients.

TL;DR: Results indicate that miR-223 is an antiangiogenic microRNAs expressed by native endothelial cells that prevents endothelial cell proliferation at least partly by targeting &bgr;1 integrin.

TL;DR: In this article, the authors identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acids.

TL;DR: Calpain inhibition may be one means of normalizing platelet miRNA processing as well as platelet function in diabetes mellitus.