J
Jiri Gut
Researcher at University of California, San Francisco
Publications - 160
Citations - 8059
Jiri Gut is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium berghei. The author has an hindex of 45, co-authored 159 publications receiving 7265 citations. Previous affiliations of Jiri Gut include University of Cape Town & Guru Nanak Dev University.
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Journal ArticleDOI
Chemical genetics of Plasmodium falciparum.
W. Armand Guiguemde,Anang A. Shelat,David Bouck,Sandra Duffy,Gregory J. Crowther,Paul H. Davis,David C. Smithson,Michele Connelly,Julie Clark,Fangyi Zhu,María Belén Jiménez-Díaz,María Santos Martínez,Emily Wilson,Abhai K. Tripathi,Jiri Gut,Elizabeth R. Sharlow,Ian Bathurst,Farah El Mazouni,Joseph W. Fowble,Isaac P. Forquer,Paula L. McGinley,Steve Castro,Iñigo Angulo-Barturen,Santiago Ferrer,Philip J. Rosenthal,Joseph L. DeRisi,David J. Sullivan,John S. Lazo,David S. Roos,Michael K. Riscoe,Margaret A. Phillips,Pradipsinh K. Rathod,Wesley C. Van Voorhis,Vicky M. Avery,R. Kiplin Guy +34 more
TL;DR: A phenotypic forward chemical genetic approach to discover new antimalarial chemotypes and structures and biological activity of the entire library are disclosed, many of which showed potent in vitro activity against drug-resistant P. falciparum strains.
Journal ArticleDOI
Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum
Erica L. Dahl,Jennifer L. Shock,Bhaskar R. Shenai,Jiri Gut,Joseph L. DeRisi,Philip J. Rosenthal +5 more
TL;DR: It is demonstrated that tetracyclines specifically block expression of the apicoplast genome, resulting in the distribution of nonfunctional apicoplasts into daughter merozoites, which leads to a slow but potent antimalarial effect.
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Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Doron C. Greenbaum,Zachary B. Mackey,Elizabeth Hansell,Patricia S. Doyle,Jiri Gut,Conor R. Caffrey,Julia Lehrman,Philip J. Rosenthal,James H. McKerrow,Kelly Chibale +9 more
TL;DR: The results suggest that thiosemicarbazones represent validated drug leads that kill several species of protozoan parasites through the inhibition of cysteine proteases as well as other novel targets.
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Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3.
TL;DR: Falcipain-3 is a second P. falciparum haemoglobinase that is particularly suited for the hydrolysis of native haemochemistry in the acidic food vacuole, and may offer optimized hydroolysis of both native ha Hemoglobin and globin peptides.
Journal ArticleDOI
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Jose N. Dominguez,Caritza León,Juan Rodrigues,Neira Gamboa de Domínguez,Jiri Gut,Philip J. Rosenthal +5 more
TL;DR: Results suggest that chalcones exert their antimalarial activity via multiple mechanisms.