Author
Jitin Yadav
Other affiliations: Risk and Insurance Management Society
Bio: Jitin Yadav is an academic researcher from Rajendra Institute of Medical Sciences. The author has contributed to research in topics: Total synthesis & Ring (chemistry). The author has an hindex of 11, co-authored 86 publications receiving 339 citations. Previous affiliations of Jitin Yadav include Risk and Insurance Management Society.
Papers published on a yearly basis
Papers
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TL;DR: A wide variety of epoxides and aziridines were converted to the corresponding β-azido alcohols and β-zido amines with sodium azide using Oxone® in aqueous acetonitrile with excellent yields at room temperature under mild reaction conditions.
Abstract: A wide variety of epoxides and aziridines were converted to the corresponding β-azido alcohols and β-azido amines with sodium azide using Oxone® in aqueous acetonitrile. The reactions were highly regioselective and efficient with excellent yields at room temperature under mild reaction conditions.
43 citations
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TL;DR: The BISAP score represents a simple way of identifying, within 24 hours of presentation, patients at greater risk of dying and the development of intermediate markers of severity, in a tertiary care centre in east central India.
Abstract: Objective: Our aim was to prospectively evaluate the accuracy of the bedside index for severity in acute pancreatitis (BISAP) score in predicting mortality, as well as intermediate markers of severity, in a tertiary care centre in east central India, which caters mostly for an economically underprivileged population. Methods: A total of 119 consecutive cases with acute pancreatitis were admitted to our institution between November 2012 and October 2014. BISAP scores were calculated for all cases, within 24 hours of presentation. Ranson’s score and computed tomography severity index (CTSI) were also established. The respective abilities of the three scoring systems to predict mortality was evaluated using trend and discrimination analysis. The optimal cut-off score for mortality from the receiver operating characteristics (ROC) curve was used to evaluate the development of persistent organ failure and pancreatic necrosis (PNec). Results: Of the 119 cases, 42 (35.2%) developed organ failure and were classified as severe acute pancreatitis (SAP), 47 (39.5%) developed PNec, and 12 (10.1%) died. The area under the curve (AUC) results for BISAP score in predicting SAP, PNec, and mortality were 0.962, 0.934 and 0.846, respectively. Ranson’s score showed a slightly lower accuracy for predicting SAP (AUC 0.956) and mortality (AUC 0.841). CTSI was the most accurate in predicting PNec, with an AUC of 0.958. The sensitivity and specificity of BISAP score, with a cut-off of � 3 in predicting mortality, were 100% and 69.2%, respectively. Conclusions: The BISAP score represents a simple way of identifying, within 24 hours of presentation, patients at greater risk of dying and the development of intermediate markers of severity. This risk stratification method can be utilized to improve clinical care and facilitate enrolment in clinical trials.
24 citations
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TL;DR: Although early recognition of intestinal injuries from blunt abdominal trauma may be difficult in all cases, it is very important due to its tremendous life threatening potential.
Abstract: Objective: To determine the presentation, anatomical distribution, diagnostic method, management and outcome of hollow viscus injury (HVI) from blunt abdominal trauma. Methods: This was a retrospective cross-sectional study including patients with blunt abdominal trauma leading to HVI admitted at Rajendra Institute of Medical Sciences, Ranchi, over a period of 4.5 years (January 2009 to July 2014). Data were retrieved from patients’medical records. Total 173 patients with HVI due to blunt abdominal trauma, who underwent laparotomy at our institute, were reviewed. Data regarding clinical presentation, anatomical distribution, management and outcome were recorded and analysed. Results: Out of 173 patients 87.1% were men and 12.9% were women. Mean age of patients was 29 ± 14.02 years. The most common site of injury was ileum (46.2%) followed by jejunum (44.5%). There were 5 gastric perforations (2.9%), 2 (1.15%) duodenal, 2 (1.15%) colonic, 2 (1.15%) sigmoidal and 2 (1.15%) rectal injuries. One caecal injury was also recorded. Road traffic accident was the most common mechanism of injury (57.2%) followed by fall from height (36.4%) and assault (6.4%). Free gas under diaphragm on erect abdomen radiography was seen in 85.5% of cases while preoperative CT Abdomen was done in 11.6% of cases. Treatment consisted of simple closure of the perforation (66.5%), resection and anastomosis (11.0%) and stoma (22.5%). Major complication was anastamotic leak which was recorded in 6.4% cases and 15.6% patients developed burst abdomen. Average hospital stay was 13 ± 6 days. Overall mortality rate was 12.7%. Conclusion: Although early recognition of intestinal injuries from blunt abdominal trauma may be difficult in all cases, it is very important due to its tremendous life threatening potential. Age of the patient, anatomical site and time of presentation are probably main prognostic factors.
20 citations
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TL;DR: A stereoselective total synthesis of phytotoxic compounds herbarumin I and stagonolide A using Crimmin's protocol for non-Evans anti-aldol approach and a ring-closing olefin metathesis reaction is described in this article.
Abstract: A stereoselective total synthesis of phytotoxic compounds herbarumin I and stagonolide A has been achieved utilizing Crimmin's protocol for non-Evans anti-aldol approach and a ring-closing olefin metathesis reaction as the key steps.
19 citations
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TL;DR: This is the first report on the alkylation of indoles with activated azetidines and it is reported that C-3 substituted indole derivatives in good to high yields and with high selectivity are produced.
Abstract: Indoles undergo smooth alkylation with N-tosylazetidines in the presence of indium(III) bromide in dichloroethane under mild conditions to produce the corresponding C-3 substituted indole derivatives in good to high yields and with high selectivity. This is the first report on the alkylation of indoles with activated azetidines.
14 citations
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TL;DR: The main findings are: Lanthanide(II) Triflates in Organic Synthesis inorganic Synthesis 2295 10.2.1.
Abstract: 2.1.8. Michael Reaction 2245 2.1.9. Others 2247 2.2. Cyclization Reactions 2248 2.2.1. Carbon Diels−Alder Reactions 2248 2.2.2. Aza-Diels−Alder Reactions 2252 2.2.3. Other Hetero-Diels−Alder Reactions 2255 2.2.4. Ionic Diels−Alder Reaction 2256 2.2.5. 1,3-Dipolar Cycloadditions 2256 2.2.6. Other Cycloaddition Reactions 2258 2.2.7. Prins-type Cyclization 2259 2.3. Friedel−Crafts Acylation and Alkylation 2259 2.4. Baylis−Hillman Reaction 2263 2.5. Radical Addition 2264 2.6. Heterocycle Synthesis 2267 2.7. Diazocarbonyl Insertion 2270 3. C−X (X ) N, O, P, Etc.) Bond Formation 2271 3.1. Aromatic Nitration and Sulfonylation 2271 3.2. Michael Reaction 2272 3.3. Glycosylation 2273 3.4. Aziridination 2275 3.5. Diazocarbonyl Insertion 2276 3.6. Ring-Opening Reactions 2277 3.7. Other C−X Bond Formations 2280 4. Oxidation and Reduction 2280 4.1. Oxidation 2280 4.2. Reduction 2281 5. Rearrangement 2283 6. Protection and Deprotection 2285 6.1. Protection 2285 6.2. Deprotection 2288 7. Polymerization 2291 8. Miscellaneous Reactions 2291 9. Lanthanide(II) Triflates in Organic Synthesis 2295 10. Conclusion 2295 11. Acknowledgment 2295 12. References 2295
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296 citations
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Marche Polytechnic University1, United Arab Emirates University2, Obafemi Awolowo University3, John Hunter Hospital4, Rambam Health Care Campus5, University of Hawaii at Manoa6, University of Santiago de Compostela7, University of California, San Diego8, Tbilisi State Medical University9, University of Maryland, Baltimore10, Russian National Research Medical University11, Virginia Commonwealth University12, State University of Campinas13, Mansoura University14, Yonsei University15, Ruhr University Bochum16, Inje University17, University of Southern California18, Erzincan University19, University of Belgrade20, Tel Aviv University21, Foothills Medical Centre22, Kyoto University23, Edendale Hospital24, University of Helsinki25, Universidad Nacional de Asunción26, University of Washington27, Pt. B.D. Sharma PGIMS Rohtak28, University of the West Indies29, University of Colorado Denver30, University of Ilorin31, Jordan University of Science and Technology32, University of Valle33, University of São Paulo34, Ehime University35, Tan Tock Seng Hospital36, Stavanger University Hospital37, University of Bergen38, Charles University in Prague39, Radboud University Nijmegen40, Harvard University41, Chang Gung University42, Sher-I-Kashmir Institute of Medical Sciences43, Royal Perth Hospital44
TL;DR: The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.
Abstract: Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs. The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.
289 citations
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TL;DR: In this article, the general discussion on green chemistry and catalysis; and solid acid catalysts are discussed in the context of a review of the last few years for various synthetic protocols.
254 citations