Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

https://www.arca.fiocruz.br/bitstream/icict/25943/2/Bezerra%20DP%20Overview%20of%20the%20therapeutic....pdf

Overview of the therapeutic potential of piplartine (piperlongumine).

Considered as the “King of spices”, black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste of other ingredients. Piper nigrum has ...

A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications.

The available drugs for diabetes, Insulin or Oral hypoglycemic agents have one or more side effects. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antihyperglycemic and antihyperlipidemic effects of Piper longum root aqueous extract (PlrAqe) in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male Wister albino rats by intraperitoneal administration of STZ (50 mg/kg.b.w). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The activities of liver and kidney functional markers were measured. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by DMRT. During the short term study the aqueous extract at a dosage of 200 mg/kg.b.w was found to possess significant antidiabetic activity after 6 h of the treatment. The administration of aqueous extract at the same dose for 30 days in STZ induced diabetic rats resulted in a significant decrease in FBG levels with the corrections of diabetic dyslipidemia compared to untreated diabetic rats. There was a significant decrease in the activities of liver and renal functional markers in diabetic treated rats compared to untreated diabetic rats indicating the protective role of the aqueous extract against liver and kidney damage and its non-toxic property. From the above results it is concluded that the plant extract is capable of managing hyperglycemia and complications of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the potential sources for the isolation of new oral anti hypoglycemic agent(s).

https://link.springer.com/content/pdf/10.1186%2F1472-6882-13-37.pdf

Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats.

Bioactive compounds from medicinal plants: Focus on Piper species

Overview for various aspects of the health benefits of Piper longum linn. fruit.

This study was made to investigate the anti-diabetic and antioxidant potential of ethanolic extract of seeds of Psoralea corylifolia L. in streptozotocin (STZ) nicotinamide induced type-2 diabetic rats. Male Albino Wistar rats (150-250 g) were taken for the study. The ethanolic extract of seeds of Psoralea corylifolia was prepared and the oral administration of this extract tested for anti-hyperglycemic activity in streptozotocin-nicotinamide induced diabetic rats showed significant effect on blood glucose level in acute and chronic study. The body weight, oral glucose tolerance test and biochemical parameter such as insulin level, liver glycogen contents, glycosylated hemoglobin, total plasma cholesterol and antioxidant parameters were estimated for all treated group and compared against diabetic control group. In oral glucose tolerance test both dose (200 and 400 mg/kg) intensively reduced external glucose level. After 28 days (chronic study) of treatment with extract the maximum reduction in blood glucose level were observed in streptozotocin-nicotinamide rats with ethanolic extract 400 mg/kg body weight per os. There were significant increase in body weight, liver glycogen content, plasma insulin level and decrease in the blood glucose, glycosylated hemoglobin level and total plasma cholesterol. However it also influences on the antioxidant parameters like decreases malondialdehyde (MDA) level and increases reduced glutathione (GSH) level. This investigation results that Psoralea corylifolia has significant antihyperglycemic and antioxidant activity.

/pdf/in-vivo-anti-diabetic-and-anti-oxidant-potential-of-psoralea-3d1lplp54m.pdf

Jitpal Kamboj

Papers

Overview for various aspects of the health benefits of Piper longum linn. fruit.

In Vivo Anti-diabetic and Anti-oxidant Potential of Psoralea corylifolia Seeds in Streptozotocin Induced Type-2 Diabetic Rats