Jiuxin Qu

Bio: Jiuxin Qu is an academic researcher from Capital Medical University. The author has contributed to research in topics: Virus & Multiplex. The author has an hindex of 1, co-authored 1 publications receiving 6 citations.

A Filippov model describing the effects of media coverage and quarantine on the spread of human influenza

Abstract: Mass-media reports on an epidemic or pandemic have the potential to modify human behaviour and affect social attitudes. Here we construct a Filippov model to evaluate the effects of media coverage and quarantine on the transmission dynamics of influenza. We first choose a piecewise smooth incidence rate to represent media reports being triggered once the number of infected individuals exceeds a certain critical level [Formula: see text] . Further, if the number of infected cases increases and exceeds another larger threshold value [Formula: see text] ( [Formula: see text] ), we consider that the incidence rate tends to a saturation level due to the protection measures taken by individuals; meanwhile, we begin to quarantine susceptible individuals when the number of susceptible individuals is larger than a threshold value Sc. Then, for each susceptible threshold value Sc, the global properties of the Filippov model with regard to the existence and stability of all possible equilibria and sliding-mode dynamics are examined, as we vary the infected threshold values [Formula: see text] and [Formula: see text] . We show generically that the Filippov system stabilizes at either the endemic equilibrium of the subsystem or the pseudoequilibrium on the switching surface or the endemic equilibrium [Formula: see text] depending on the choice of the threshold values. The findings suggest that proper combinations of infected and susceptible threshold values can maintain the number of infected individuals either below a certain threshold level or at a previously given level.

A two-thresholds policy for a Filippov model in combating influenza

Abstract: This work designs a two-thresholds policy for a Filippov model in combating influenza, so as to estimate when and whether to take control strategies, including the media coverage, antiviral treatment of infected individuals and vaccination of susceptible population By introducing two tolerance thresholds $$S_{c}$$ and $$I_{c}$$ of susceptible and infected individuals, the two-thresholds policy is designed as: a vaccination program is implemented when the number of susceptible individuals is above $$S_{c}$$ ; an antiviral treatment strategy is taken and the mass media begins to report information about influenza when the infection number is larger than $$I_{c}$$ ; no control strategies are required in other cases Furthermore, the global dynamics of the model are analyzed by varying these two thresholds, including the existence and dynamics of sliding mode, and the existence and global stability of equilibrium It is shown that the model solutions ultimately converge to a pseudoequilibrium or a pseudoattractor on the switching surface, or a real equilibrium The obtained results indicate that, by choosing susceptible and infected thresholds properly, the infection number can be remained below or at an acceptable level

Facilely prepared low-density DNA monolayer-based electrochemical biosensor with high detection performance in human serum.

Abstract: Presently, most reported electrochemical biosensors, for highly sensitive and selective detection of nucleic acid, still require multiple, time-consuming assembly steps and high-consumption DNA probes as well as lack good performance in human serum, which greatly limit their applicability. Herein, an easy-to-fabricate electrochemical DNA biosensor constructed by assembly of bovine serum albumin (BSA) followed with direct incubation of amplified products has been proposed. This method combined terminal deoxynucleoside transferase (TdTase)–mediated isothermal amplification and polyHRP catalysis to achieve dual-signal enhancement, and was featured with low-density DNA monolayer for its employment of only 2 nM capture probes. Surprisingly, based on the low-density DNA monolayer, the steric hindrance effect of polyHRP could effectively restrain the background compared with HRP, which further pushes the signal-to-noise (S/N) ratio to 70 than that of most currently available methods. Additionally, this strategy also showed favorable specificity and powerful anti-interference in human serum, and thus potentially attractive for diagnosis of diseases.

Progress and Current Status of Influenza Researches in China.

Abstract: Influenza pandemics with different extent occur every year in the world. It can cause high morbidity and mortality, arouse fear panic in public, and attract extensive attention worldwide. This paper reviews the research progress in epidemiological characteristics, detection methods, pathogenesis, treatment and prophylactic measures of influenza in China. It will be helpful for us to understand the current situation of influenza.