J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Jo Vandesompele,Katleen De Preter,Filip Pattyn,Bruce Poppe,Nadine Van Roy,Anne De Paepe,Franki Speleman +6 more
TL;DR: The normalization strategy presented here is a prerequisite for accurate RT-PCR expression profiling, which opens up the possibility of studying the biological relevance of small expression differences.
Journal ArticleDOI
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Jo Vandesompele,Carl T. Wittwer,Carl T. Wittwer +12 more
TL;DR: The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines target the reliability of results to help ensure the integrity of the scientific literature, promote consistency between laboratories, and increase experimental transparency.
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qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
TL;DR: Advanced and universally applicable models for relative quantification and inter-run calibration with proper error propagation along the entire calculation track are outlined in qBase, a free program for the management and automated analysis of qPCR data.
Journal ArticleDOI
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Li Ma,Jennifer J. Young,Harsha K. Prabhala,Elizabeth Pan,Pieter Mestdagh,Daniel Muth,Julie Teruya-Feldstein,Ferenc Reinhardt,Tamer T. Onder,Scott Valastyan,Frank Westermann,Frank Speleman,Jo Vandesompele,Robert A. Weinberg +13 more
TL;DR: It is shown that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness, and a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis
Journal ArticleDOI
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Martin Peifer,Lynnette Fernandez-Cuesta,Martin L. Sos,Julie George,Danila Seidel,Lawryn H. Kasper,Dennis Plenker,Frauke Leenders,Ruping Sun,Thomas Zander,Roopika Menon,Mirjam Koker,Ilona Dahmen,Christian Müller,Vincenzo Di Cerbo,Hans Ulrich Schildhaus,Janine Altmüller,Ingelore Baessmann,Christian Becker,Bram De Wilde,Jo Vandesompele,Diana Böhm,Sascha Ansén,Franziska Gabler,Ines Wilkening,Stefanie Heynck,Johannes M. Heuckmann,Xin Lu,Scott L. Carter,Kristian Cibulskis,Shantanu Banerji,Gad Getz,Kwon-Sik Park,Daniel Rauh,Christian Grütter,Matthias Fischer,Laura Pasqualucci,Gavin M. Wright,Zoe Wainer,Prudence A. Russell,Iver Petersen,Yuan Chen,Erich Stoelben,Corinna Ludwig,Philipp A. Schnabel,Hans Hoffmann,Thomas Muley,Michael Brockmann,Walburga Engel-Riedel,Lucia Anna Muscarella,Vito Michele Fazio,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egber Smit,Daniëlle A M Heideman,Peter J.F. Snijders,Federico Cappuzzo,C. Ligorio,Stefania Damiani,John K. Field,Steinar Solberg,Odd Terje Brustugun,Marius Lund-Iversen,Jörg Sänger,Joachim H. Clement,Alex Soltermann,Holger Moch,Walter Weder,Benjamin Solomon,Jean-Charles Soria,Pierre Validire,Benjamin Besse,Elisabeth Brambilla,Christian Brambilla,Sylvie Lantuejoul,Philippe Lorimier,Peter M. Schneider,Michael Hallek,William Pao,Matthew Meyerson,Matthew Meyerson,Julien Sage,Jay Shendure,Robert Schneider,Robert Schneider,Reinhard Büttner,Jürgen Wolf,Peter Nürnberg,Sven Perner,Lukas C. Heukamp,Paul K. Brindle,Stefan A. Haas,Roman K. Thomas +94 more
TL;DR: This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.