J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
Papers
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Journal ArticleDOI
Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.
Tom Van Maerken,Liesbeth Ferdinande,Jasmien Taildeman,Irina Lambertz,Nurten Yigit,Liesbeth Vercruysse,Ali Rihani,Martin Michaelis,Jindrich Cinatl,Claude Cuvelier,Jean-Christophe Marine,Anne De Paepe,Marc Bracke,Frank Speleman,Jo Vandesompele +14 more
TL;DR: Nutlin-3 activates the p53 pathway and suppresses tumor growth and reduction in the extent of metastatic disease in this model system of chemoresistant neuroblastoma, provided that wild-type p53 is present.
Book ChapterDOI
Selection of Reliable Reference Genes for RT-qPCR Analysis
Jan Hellemans,Jo Vandesompele +1 more
TL;DR: This chapter describes how a pilot study can be set up to identify the best set of reference genes to be used for normalization of qPCR data and how the data from such studies can be used to identify reference genes for subsequent validation studies on smaller sets of selected genes.
Journal ArticleDOI
Rapid detection of VHL exon deletions using real-time quantitative PCR.
Jasmien Hoebeeck,Rob B. van der Luijt,Bruce Poppe,Els De Smet,Nurten Yigit,Kathleen Claes,Richard Zewald,Gert-Jan de Jong,Anne De Paepe,Frank Speleman,Jo Vandesompele +10 more
TL;DR: Q-PCR is proposed as the method of choice for fast (within 3.5 h), accurate and sensitive (ng amount of input DNA) exon deletion screening in routine DNA diagnosis of VHL disease and similar assays can be designed for deletion screened in other genetic disorders.
Journal ArticleDOI
MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease
Griet Conickx,Pieter Mestdagh,Francisco Avila Cobos,Fien M. Verhamme,Tania Maes,Bart M. Vanaudenaerde,Leen J M Seys,Lies Lahousse,Richard Kim,Alan Hsu,Peter A. B. Wark,Peter A. B. Wark,Philip M. Hansbro,Guy Joos,Jo Vandesompele,Ken R. Bracke,Guy Brusselle +16 more
TL;DR: In vitro and in vivo perturbation of miR‐218‐5p combined with RNA sequencing and gene set enrichment analysis was used to elucidate its functional role in COPD pathogenesis and highlight a role for miR-218‐ 5p in the pathogenesis of COPD.
Journal ArticleDOI
Cancer-associated adipose tissue promotes breast cancer progression by paracrine Oncostatin M and Jak/STAT3 signaling.
Lore Lapeire,An Hendrix,Kathleen Lambein,Mieke Van Bockstal,Geert Braems,Rudy Van den Broecke,Ridha Limame,Pieter Mestdagh,Jo Vandesompele,Christian Vanhove,Dawn M. Maynard,Camille Lehuédé,Catherine Muller,Philippe Valet,Christian Gespach,Marc Bracke,Veronique Cocquyt,Hannelore Denys,Olivier De Wever +18 more
TL;DR: It is shown that breast cancer-associated adipose tissue from freshly isolated tumors promotes F-actin remodeling, cellular scattering, invasiveness, and spheroid reorganization of cultured breast cancer cells.