J
Jo Vandesompele
Researcher at Ghent University
Publications - 406
Citations - 67052
Jo Vandesompele is an academic researcher from Ghent University. The author has contributed to research in topics: Neuroblastoma & microRNA. The author has an hindex of 88, co-authored 383 publications receiving 59368 citations. Previous affiliations of Jo Vandesompele include Washington University in St. Louis & Ghent University Hospital.
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Journal ArticleDOI
ArrayCGH-based classification of neuroblastoma into genomic subgroups
Evi Michels,Jo Vandesompele,Katleen De Preter,Jasmien Hoebeeck,Joëlle Vermeulen,Alexander Schramm,Jan J. Molenaar,Björn Menten,Bárbara Marques,Raymond L. Stallings,Valérie Combaret,Christine Devalck,Anne De Paepe,Rogier Versteeg,Angelika Eggert,Genevieve Laureys,Nadine Van Roy,Frank Speleman +17 more
TL;DR: It is proposed that genome‐wide assessment of copy number alterations should ideally be included in the genetic workup of neuroblastoma in order to improve therapeutic stratification in conjunction with other features such as age at diagnosis, tumor stage, and gene expression signatures.
Journal ArticleDOI
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation
David Nittner,Irina Lambertz,Irina Lambertz,Frederic Clermont,Pieter Mestdagh,Corinna Köhler,Søren Jensby Nielsen,Aart G. Jochemsen,Franki Speleman,Jo Vandesompele,Michael A. Dyer,Michael A. Dyer,Alexander Schramm,Johannes H. Schulte,Jean-Christophe Marine +14 more
TL;DR: It is shown that Dicer1 targeting prevents retinoblastoma formation in mice by synthetic lethality with combined inactivation of p53 and Rb, and a proof-of-concept that targeting miRNAs may potentially represent a general approach for synthetic lethal targeting of cancer cells that harbour specific cancer-inducing genotypes.
Book ChapterDOI
Real-time quantitative PCR as an alternative to Southern blot or fluorescence in situ hybridization for detection of gene copy number changes.
TL;DR: The procedure of how to develop an assay for the detection of gene copy number changes for your gene of interest is outlined and a validated assay is described for the Detection of germline VHL exon deletions and for determination of MYCN copy numbers in tumor samples are described.
Journal ArticleDOI
Erratum: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes (Genome Biology)
Katleen De Preter,Jo Vandesompele,Nurten Yigit,Anne De Paepe,Frank Speleman,Pierre Heimann,Siv Beckman,Sven Påhlman,Alexander Schramm,Angelika Eggert,Raymond L. Stallings,Yves Benoit,Genevieve Laureys,Marleen Renard +13 more
TL;DR: A correction to Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights Neuroblastoma candidate genes by K De Preter and F Speleman.
Journal ArticleDOI
Non-coding RNAs in the pathogenesis of COPD.
TL;DR: The miRNA expression patterns in lungs of patients with COPD and in mouse models are discussed and various miRNAs involved in COPD pathogenesis are highlighted, providing a short introduction to this more recently discovered group of non-coding RNAs.