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Joachim Heinrich

Bio: Joachim Heinrich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Population & Asthma. The author has an hindex of 136, co-authored 1309 publications receiving 76887 citations. Previous affiliations of Joachim Heinrich include Politehnica University of Bucharest & Universidade Nova de Lisboa.


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TL;DR: Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

2,632 citations

01 Jan 2010
TL;DR: 18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

1,953 citations

Journal ArticleDOI
TL;DR: The present study suggests that the size distribution of ambient particles helps to elucidate the properties of ambient aerosols responsible for health effects.
Abstract: The association between fine and ultrafine particles and respiratory health was studied in adults with a history of asthma in Erfurt, Eastern Germany. Twenty-seven nonsmoking asthmatics recorded their peak expiratory flow (PEF) and respiratory symptoms daily. The size distribution of ambient particles in the range of 0.01 to 2.5 microm was determined with an aerosol spectrometer during the winter season 1991-1992. Most of the particles (73%) were in the ultrafine fraction (smaller than 0.1 microm in diameter), whereas most of the mass (82%) was attributable to particles in the size range of 0.1 to 0.5 microm. Because these two fractions did not have similar time courses (correlation coefficient r = 0.51), a comparison of their health effects was possible. Both fractions were associated with a decrease of PEF and an increase in cough and feeling ill during the day. Health effects of the 5-d mean of the number of ultrafine particles were larger than those of the mass of the fine particles. In addition, the effects of the number of the ultrafine particles on PEF were stronger than those of particulate matter smaller than 10 microm (PM10). Therefore, the present study suggests that the size distribution of ambient particles helps to elucidate the properties of ambient aerosols responsible for health effects.

1,290 citations

Journal ArticleDOI
TL;DR: In this article, potential pathways linking greenspace to health are presented in three domains, which emphasize three general functions of greenspace: reducing harm (e.g., reducing exposure to air pollution, noise and heat), restoring capacities (i.e., attention restoration and physiological stress recovery), and encouraging physical activity and facilitating social cohesion). Interrelations between among the three domains are also noted.

1,187 citations

Journal ArticleDOI
Rob Beelen1, Ole Raaschou-Nielsen, Massimo Stafoggia, Zorana Jovanovic Andersen2, Gudrun Weinmayr3, Gudrun Weinmayr4, Barbara Hoffmann4, Kathrin Wolf, Evangelia Samoli5, Paul Fischer, Mark J. Nieuwenhuijsen, Paolo Vineis6, Wei W. Xun7, Wei W. Xun6, Klea Katsouyanni5, Konstantina Dimakopoulou5, Anna Oudin8, Bertil Forsberg8, Lars Modig8, Aki S. Havulinna9, Timo Lanki9, Anu W. Turunen9, Bente Oftedal10, Wenche Nystad10, Per Nafstad10, Per Nafstad11, Ulf de Faire12, Nancy L. Pedersen12, Claes-Göran Östenson12, Laura Fratiglioni12, Johanna Penell12, Michal Korek12, Göran Pershagen12, Kirsten Thorup Eriksen, Kim Overvad13, Thomas Ellermann13, Marloes Eeftens1, Petra H.M. Peeters6, Petra H.M. Peeters14, Kees Meliefste1, Meng Wang1, Bas Bueno-de-Mesquita, Dorothea Sugiri4, Ursula Krämer4, Joachim Heinrich, Kees de Hoogh6, Timothy J. Key15, Annette Peters, Regina Hampel, Hans Concin, Gabriele Nagel3, Alex Ineichen16, Alex Ineichen17, Emmanuel Schaffner16, Emmanuel Schaffner17, Nicole Probst-Hensch17, Nicole Probst-Hensch16, Nino Künzli17, Nino Künzli16, Christian Schindler16, Christian Schindler17, Tamara Schikowski16, Tamara Schikowski17, Martin Adam17, Martin Adam16, Harish C. Phuleria16, Harish C. Phuleria17, Alice Vilier18, Alice Vilier19, Françoise Clavel-Chapelon19, Françoise Clavel-Chapelon18, Christophe Declercq, Sara Grioni, Vittorio Krogh, Ming-Yi Tsai20, Ming-Yi Tsai17, Ming-Yi Tsai16, Fulvio Ricceri, Carlotta Sacerdote21, C Galassi21, Enrica Migliore21, Andrea Ranzi, Giulia Cesaroni, Chiara Badaloni, Francesco Forastiere, Ibon Tamayo22, Pilar Amiano22, Miren Dorronsoro22, Michail Katsoulis, Antonia Trichopoulou, Bert Brunekreef1, Bert Brunekreef14, Gerard Hoek1 
TL;DR: In this article, the authors investigated the association between natural-cause mortality and long-term exposure to several air pollutants, such as PM2.5, nitrogen oxides, and NOx.

1,056 citations


Cited by
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[...]

08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Journal ArticleDOI
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Abstract: Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease worldwide, according to a study published by the World Bank/World Health Organization. Yet, COPD remains relatively unknown or ignored by the public as well as public health and government officials. In 1998, in an effort to bring more attention to COPD, its management, and its prevention, a committed group of scientists encouraged the U.S. National Heart, Lung, and Blood Institute and the World Health Organization to form the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Among the important objectives of GOLD are to increase awareness of COPD and to help the millions of people who suffer from this disease and die prematurely of it or its complications. The first step in the GOLD program was to prepare a consensus report, Global Strategy for the Diagnosis, Management, and Prevention of COPD, published in 2001. The present, newly revised document follows the same format as the original consensus report, but has been updated to reflect the many publications on COPD that have appeared. GOLD national leaders, a network of international experts, have initiated investigations of the causes and prevalence of COPD in their countries, and developed innovative approaches for the dissemination and implementation of COPD management guidelines. We appreciate the enormous amount of work the GOLD national leaders have done on behalf of their patients with COPD. Despite the achievements in the 5 years since the GOLD report was originally published, considerable additional work is ahead of us if we are to control this major public health problem. The GOLD initiative will continue to bring COPD to the attention of governments, public health officials, health care workers, and the general public, but a concerted effort by all involved in health care will be necessary.

17,023 citations

Journal ArticleDOI
Georges Aad1, T. Abajyan2, Brad Abbott3, Jalal Abdallah4  +2964 moreInstitutions (200)
TL;DR: In this article, a search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7×10−9.

9,282 citations