Author
Joachim Wiskemann
Other affiliations: German Cancer Research Center, Heidelberg University, Guy's and St Thomas' NHS Foundation Trust ...read more
Bio: Joachim Wiskemann is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 28, co-authored 126 publications receiving 3030 citations. Previous affiliations of Joachim Wiskemann include German Cancer Research Center & Heidelberg University.
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University of British Columbia1, Oregon Health & Science University2, Heidelberg University3, Utrecht University4, Northern Arizona University5, University of Alberta6, George Mason University7, Wingate University8, American Cancer Society9, University of California, San Francisco10, Penn State Cancer Institute11
TL;DR: Enough evidence was available to conclude that specific doses of aerobic, combined aerobic plus resistance training, and/or resistance training could improve common cancer-related health outcomes, including anxiety, depressive symptoms, fatigue, physical functioning, and health-related quality of life.
Abstract: PurposeThe number of cancer survivors worldwide is growing, with over 15.5 million cancer survivors in the United States alone—a figure expected to double in the coming decades. Cancer survivors face unique health challenges as a result of their cancer diagnosis and the impact of treatments
1,174 citations
VU University Medical Center1, University of Alberta2, Edith Cowan University3, Netherlands Cancer Institute4, University of South Florida5, Utrecht University6, German Cancer Research Center7, Yale University8, Queensland University of Technology9, University of Maryland, Baltimore10, European University of Madrid11, Maastricht University12, University of Groningen13, University of Amsterdam14, University of Edinburgh15, University of Birmingham16, University of Glasgow17, University of Antwerp18, University of Oslo19, University of Hamburg20, University of Adelaide21, University of Newcastle22, Guy's and St Thomas' NHS Foundation Trust23, University Hospital Heidelberg24, King's College London25, Pennsylvania State University26, Oregon Health & Science University27, Johns Hopkins University28
TL;DR: In conclusion, exercise, and particularly supervised exercise, effectively improves QoL and PF in patients with cancer with different demographic and clinical characteristics during and following treatment.
374 citations
TL;DR: RT was shown to be associated with clinically important positive effects on muscular function and body composition in patients during treatment or in long-term follow-up.
Abstract: STRASSER, B., K. STEINDORF, J. WISKEMANN, and C. M. ULRICH. Impact of Resistance Training in Cancer Survivors: A MetaAnalysis. Med. Sci. Sports Exerc., Vol. 45, No. 11, pp. 2080–2090, 2013. Purpose: Current evidence suggests many health benefits from physical activity during and after cancer treatment. However, the optimal exercise program for cancer survivors has not yet been established. The purpose of this meta-analysis was to summarize evidence for the efficacy of resistance training (RT) interventions to improve muscle strength and body composition among adult cancer survivors. We also investigate potential dose–response relationships between intensity, duration, and frequency of RT and assessed outcomes. Methods: A systematic literature review of the Clinical Trial Register, Cochrane Trial Register, MEDLINE, and EMBASE literature databases was undertaken. Studies were included if they were randomized controlled trials (RCT) comparing RT with an exercise or nonexercise control group in cancer survivors during and after treatment. Thirteen articles from 11 RCT met our inclusion criteria. We performed a random-effects meta-analysis to determine weighted mean differences (WMD) with 95% confidence intervals using the Cochrane Review Manager 5.0.25. A random-effects metaregression model was performed to examine dose–response relationships between RT variables and assessed outcomes. Results: Quantitative evidence shows a large effect of RT on lower-limb and upper-limb muscle strength (WMD: +14.57 kg, P = 0.0005 and +6.90 kg, P G 0.00001, respectively) and moderate effects on lean body mass and percentage of body fat (WMD: +1.07 kg, P G 0.0001 and j2.08%, P = 0.003, respectively). A small positive effect of RT was noted on Functional Assessment of Cancer Therapy–Fatigue (P = 0.05). Upper-limb muscle strength and percentage of body fat improved to a greater extent when RT interventions were of low to moderate intensity (e75% one-repetition maximum, P = 0.042). Conclusions: RT was shown to be associated with clinically important positive effects on
226 citations
TL;DR: This partly supervised exercise intervention is beneficial for patients undergoing allo-HSCT and because of low personnel requirements, it might be valuable to integrate such a program into standard medical care.
224 citations
TL;DR: In this article, the authors investigated whether resistance exercise during chemotherapy provides benefits on fatigue and quality of life (QoL) beyond potential psychosocial effects of group-based interventions, and they found that resistance exercise appeared to mitigate physical fatigue and maintain QoL during chemotherapy beyond psychossocial effects inherent to supervised, groupbased settings.
Abstract: Multiple exercise interventions have shown beneficial effects on fatigue and quality of life (QoL) in cancer patients, but various psychosocial interventions as well. It is unclear to what extent the observed effects of exercise interventions are based on physical adaptations or rather on psychosocial factors associated with supervised, group-based programs. It needs to be determined which aspects of exercise programs are truly effective. Therefore, we aimed to investigate whether resistance exercise during chemotherapy provides benefits on fatigue and QoL beyond potential psychosocial effects of group-based interventions. One-hundred-one breast cancer patients starting chemotherapy were randomly assigned to resistance exercise (EX) or a relaxation control (RC) group. Both interventions were supervised, group-based, 2/week over 12 weeks. The primary endpoint fatigue was assessed with a 20-item multidimensional questionnaire, QoL with the EORTC QLQ-C30/BR23. Analyses of covariance for individual changes from baseline to Week 13 were calculated. In RC, total and physical fatigue worsened during chemotherapy, whereas EX showed no such impairments (between-group p = 0.098 and 0.052 overall, and p = 0.038 and 0.034 among patients without severe baseline depression). Differences regarding affective or cognitive fatigue were not significant. Benefits of EX were also seen to affect role and social function. Effect sizes were between 0.43 and 0.48. Explorative analyses indicated significant effect modification by thyroxin use (p-interaction = 0.044). In conclusion, resistance exercise appeared to mitigate physical fatigue and maintain QoL during chemotherapy beyond psychosocial effects inherent to supervised group-based settings. Thus, resistance exercise could be an integral part of supportive care for breast cancer patients undergoing chemotherapy.
190 citations
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Journal Article•
TL;DR: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs?
Abstract: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs? Issues: Selection, maturation, history, mortality, testing, regression towrd the mean, selection by maturation, treatment by mortality, treatment by testing, measured treatment variables Increase: Eliminate the threats, above all do experimental manipulations, random assignment, and counterbalancing.
2,006 citations
University of Freiburg1, University of Alberta2, University of Milan3, Western General Hospital4, Medical University of Vienna5, Bond University6, Norwegian University of Science and Technology7, Beatson West of Scotland Cancer Centre8, Karlstad University9, Sapienza University of Rome10, University of Basel11, University of Lisbon12, University of St. Gallen13, HAN University of Applied Sciences14, Université libre de Bruxelles15
TL;DR: These evidence-based guidelines were developed to translate current best evidence and expert opinion into recommendations for multi-disciplinary teams responsible for identification, prevention, and treatment of reversible elements of malnutrition in adult cancer patients.
1,740 citations
TL;DR: This eighth edition of exercise physiology is updated with the latest research in the field to give you easy to understand up to date coverage of how nutrition energy transfer and exercise training affect human performance.
1,328 citations
University of British Columbia1, Oregon Health & Science University2, Heidelberg University3, Utrecht University4, Northern Arizona University5, University of Alberta6, George Mason University7, Wingate University8, American Cancer Society9, University of California, San Francisco10, Penn State Cancer Institute11
TL;DR: Enough evidence was available to conclude that specific doses of aerobic, combined aerobic plus resistance training, and/or resistance training could improve common cancer-related health outcomes, including anxiety, depressive symptoms, fatigue, physical functioning, and health-related quality of life.
Abstract: PurposeThe number of cancer survivors worldwide is growing, with over 15.5 million cancer survivors in the United States alone—a figure expected to double in the coming decades. Cancer survivors face unique health challenges as a result of their cancer diagnosis and the impact of treatments
1,174 citations