J
Joan Goverman
Researcher at University of Washington
Publications - 62
Citations - 6870
Joan Goverman is an academic researcher from University of Washington. The author has contributed to research in topics: Cytotoxic T cell & Myelin basic protein. The author has an hindex of 34, co-authored 59 publications receiving 6190 citations.
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Journal ArticleDOI
Autoimmune T cell responses in the central nervous system
TL;DR: This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity.
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A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis
TL;DR: It is demonstrated that myelin-specific CD8+ T cells induce severe CNS autoimmunity in mice, and data suggest that myelinated T cells could function as effector cells in the pathogenesis of MS.
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Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells
TL;DR: It is demonstrated that T cells that are specific for different myelin epitopes generate populations characterized by different T helper type 17 (TH17) to T helpertype 1 (TH1) ratios depending on the functional avidity of interactions between TCR and peptide-MHC complexes.
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T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
Jeffrey M. Critchfield,Michael K. Racke,Juan Carlos Zúñiga-Pflücker,Barbara Cannella,Cedric S. Raine,Joan Goverman,Michael J. Lenardo +6 more
TL;DR: This feedback regulatory mechanism attenuates the immune response by deleting a portion of newly dividing, antigen-reactive T cells and abrogated the clinical and pathological signs of autoimmune encephalomyelitis in mice after repetitive administration of myelin basic protein.
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Active induction of experimental allergic encephalomyelitis.
Ingunn M. Stromnes,Joan Goverman +1 more
TL;DR: This protocol details a method to actively induce experimental allergic encephalomyelitis (EAE), a widely used animal model for studies of multiple sclerosis, by immunization with myelin antigens emulsified in adjuvant.