J
Joana Liu Donaher
Researcher at Massachusetts Institute of Technology
Publications - 13
Citations - 9130
Joana Liu Donaher is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cyclin D & Mesenchymal stem cell. The author has an hindex of 11, co-authored 11 publications receiving 8464 citations.
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Journal ArticleDOI
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
TL;DR: A mechanistic link between Twist, EMT, and tumor metastasis is established, suggesting that Twist contributes to metastasis by promoting an epithelial-mesenchymal transition (EMT).
Journal ArticleDOI
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
Piotr Sicinski,Joana Liu Donaher,Susan B. Parker,Susan B. Parker,Tiansen Li,Amin Fazeli,Humphrey Gardner,Sandra Z. Haslam,Roderick T. Bronson,Stephen J. Elledge,Robert A. Weinberg +10 more
TL;DR: In adult mutant females, the breast epithelial compartment fails to undergo the massive proliferative changes associated with pregnancy despite normal levels of ovarian steroid hormones, suggesting that steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1.
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Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
TL;DR: In vivo, the requirement of "reversible EMT" in tumor metastasis is demonstrated and may resolve the controversy on the importance of EMT in carcinoma metastasis.
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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Brian Elenbaas,Lisa Spirio,Frederick C. Koerner,Mark D. Fleming,Drazen B. Zimonjic,Joana Liu Donaher,Nicholas C. Popescu,William C. Hahn,Robert A. Weinberg +8 more
TL;DR: It is shown that introduction of three genes encoding the SV40 large-T antigen, the telomerase catalytic subunit, and an H-Ras oncoprotein into primary HMECs results in cells that form tumors when transplanted subcutaneously or into the mammary glands of immunocompromised mice.
Journal ArticleDOI
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
Wenjun Guo,Zuzana Keckesova,Joana Liu Donaher,Tsukasa Shibue,Verena Tischler,Ferenc Reinhardt,Shaul Shalev Itzkovitz,Aurelia Noske,Ursina Zürrer-Härdi,George W. Bell,Wai Leong Tam,Sendurai A. Mani,Alexander van Oudenaarden,Robert A. Weinberg +13 more
TL;DR: It is shown that coexpression of Slug and Sox9 promotes the tumorigenic and metastasis-seeding abilities of human breast cancer cells and is associated with poor patient survival, providing direct evidence that human breast cancers stem cells are controlled by key regulators similar to those operating in normal murine MaSCs.