J
Joanna Bloom
Researcher at New York University
Publications - 13
Citations - 2335
Joanna Bloom is an academic researcher from New York University. The author has contributed to research in topics: Ubiquitin & Cell cycle. The author has an hindex of 12, co-authored 13 publications receiving 2248 citations. Previous affiliations of Joanna Bloom include Yale University & Rockefeller University.
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Journal ArticleDOI
Multiple levels of cyclin specificity in cell-cycle control.
Joanna Bloom,Frederick R. Cross +1 more
TL;DR: In budding yeast, a single Cdk is activated by multiple cyclins, and the ability of these cyclins to target specific proteins and to initiate different cell-cycle events might reflect the timing of the expression of the cyclins.
Journal ArticleDOI
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.
Gil Bornstein,Joanna Bloom,Danielle Sitry-Shevah,Keiko Nakayama,Michele Pagano,Avram Hershko +5 more
TL;DR: It is shown that p21 is a good substrate for an SCF (Skp1-Cullin1-F-boxprotein) ubiquitin ligase complex, which contains the F-box protein Skp2 (S phase kinase-associated protein 2) and the accessory protein Cks1 (cyclin kinase subunit 1).
Journal ArticleDOI
Deregulated degradation of the cdk inhibitor p27 and malignant transformation.
Joanna Bloom,Michele Pagano +1 more
TL;DR: This review will focus on the regulation of p27 proteolysis and its consequences for tumorigenesis.
Journal ArticleDOI
Proteasome-Mediated Degradation of p21 via N-Terminal Ubiquitinylation
TL;DR: It is suggested that the site of the ubiquitin chain is critical in making p21 a competent substrate for the proteasome and the presence of lysines is dispensable for p21 ubiquitinylation in vivo.
Journal ArticleDOI
Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes.
Elizabeth W. Newcomb,Henry Cohen,Suzanne R. Lee,Sandhya K. Bhalla,Joanna Bloom,Roberta L. Hayes,Douglas C. Miller +6 more
TL;DR: The clinical outcome among patients with GBM showed no significant differences within each age category for any GBM variant including the progressive and de novo GBM variants indicating similar biologic behavior despite different genotypes.