J
Joanna Groden
Researcher at Ohio State University
Publications - 28
Citations - 7893
Joanna Groden is an academic researcher from Ohio State University. The author has contributed to research in topics: Adenomatous polyposis coli & Gene. The author has an hindex of 20, co-authored 28 publications receiving 7755 citations. Previous affiliations of Joanna Groden include University of Cincinnati Academic Health Center & University of Utah.
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Journal ArticleDOI
Identification and characterization of the familial adenomatous polyposis coli gene
Joanna Groden,Andrew Thliveris,Andrew Thliveris,Wade S. Samowitz,M. Carlson,Lawrence Gelbert,Lawrence Gelbert,Hans Albertsen,Geoff Joslyn,Geoff Joslyn,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes located within a 100 kb region deleted in two of the patients, and data have established that DP2.5 is the APC gene.
Journal ArticleDOI
The Bloom's syndrome gene product is homologous to RecQ helicases
Nathan A. Ellis,Joanna Groden,Tian Zhang Ye,Joel E. Straughen,David J. Lennon,Susan Ciocci,Maria Proytcheva,James German +7 more
TL;DR: In this article, a candidate for Bloom's syndrome was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been assigned by somatic crossover point mapping.
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Identification of deletion mutations and three new genes at the familial polyposis locus
Geoff Joslyn,Geoff Joslyn,M. Carlson,Andrew Thliveris,Andrew Thliveris,Hans Albertsen,Lawrence Gelbert,Lawrence Gelbert,Wade S. Samowitz,Joanna Groden,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC) and two new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle.
Journal ArticleDOI
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.
Kenneth W. Kinzler,Mef Nilbert,Bert Vogelstein,Tracy M. Bryan,Daniel B. Levy,Kelly J. Smith,Antoneite C. Preisinger,Stanley R. Hamilton,Phil Hedge,Alex Markham,M. Carlson,Geoff Joslyn,Joanna Groden,Ray White,Yoshoi Miki,Yasuo Miyoshi,Isamu Nishisho,Yusuke Nakamura +17 more
TL;DR: A gene, MCC, which encodes an 829-amino acid protein with a short region of similarity to the G protein-coupled m3 muscarinic acetylcholine receptor is identified and is a candidate for the putative colorectal tumor suppressor gene located at chromosome region 5q21.
Journal ArticleDOI
Alleles of the APC gene: An attenuated form of familial polyposis
Lisa Spirio,Sylviane Olschwang,Joanna Groden,Margaret Robertson,Wade S. Samowitz,Geoff Joslyn,Lawrence Gelbert,Andrew Thliveris,M. Carlson,Brith Otterud,Henry T. Lynch,Patrice Watson,Patrick M. Lynch,Pierre Laurent-Puig,Randall W. Burt,John P. Hughes,Gilles Thomas,Mark Leppert,Ray White +18 more
TL;DR: Four distinct mutations in the APC gene have now been identified in seven AAPC families, and they differ in that the four mutated sites are located very close to one another and nearer the 5' end of theAPC gene than any base substitutions or small deletions yet discovered in patients with classical APC.